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Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia: A Randomized Clinical Trial.

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Title: Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia: A Randomized Clinical Trial.
Authors: Collins SP; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Veterans Affairs Tennessee Valley Healthcare System, Geriatric Research, Education and Clinical Center, Nashville, Tennessee., Shotwell MS; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee., Strich JR; Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland., Gibbs KW; Department of Medicine, Wake Forest University, Winston-Salem, North Carolina., de Wit M; Department of Medicine, Virginia Commonwealth University, Richmond., Files DC; Department of Medicine, Wake Forest University, Winston-Salem, North Carolina., Harkins M; Department of Internal Medicine, University of New Mexico, Albuquerque., Hudock K; Department of Medicine, University of Cincinnati, Cincinnati, Ohio., Merck LH; Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond., Moskowitz A; Department of Medicine, Montefiore Medical Center, Bronx, New York., Apodaca KD; Department of Internal Medicine, University of New Mexico, Albuquerque., Barksdale A; Department of Medicine, University of Nebraska Medical Center, Omaha., Safdar B; Department of Medicine, Yale University, New Haven, Connecticut., Javaheri A; Department of Medicine, Washington University and John Cochran VA Medical Center, St Louis, Missouri., Sturek JM; Department of Medicine, University of Virginia, Charlottesville., Schrager H; Department of Medicine, Tufts School of Medicine, Newton-Wellesley Hospital, Newton, Massachusetts., Iovine NM; Department of Medicine, University of Florida, Gainesville., Tiffany B; Dignity Health, Phoenix, Arizona., Douglas I; Department of Medicine, Denver Health Medical Center, Denver, Colorado., Levitt J; Department of Medicine, Stanford University, Stanford, California., Ginde AA; Department of Emergency Medicine, University of Colorado, Aurora., Hager DN; Department of Medicine, Johns Hopkins University, Baltimore, Maryland., Shapiro N; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Duggal A; Department of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio., Khan A; Department of Medicine, Oregon Health and Science University, Portland., Lanspa M; Department of Medicine, Intermountain Medical Center, Murray, Utah., Chen P; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California., Gentile N; Department of Emergency Medicine, Temple University, Philadelphia, Pennsylvania., Harris E; Department of Medicine, University of Utah Health Sciences, Salt Lake City., Gong M; Department of Medicine, Jack D. Weiler Hospital, Albert Einstein College of Medicine, Bronx, New York., Sellers S; Department of Medicine, University of North Carolina, Chapel Hill., Goodwin AJ; Department of Medicine, Medical University of South Carolina, Charleston., Tidswell MA; Department of Medicine, Baystate Health, Springfield, Massachusetts., Filbin M; Department of Emergency Medicine, Massachusetts General Hospital, Boston., Desai N; Department of Medicine, St Alexius Medical Center, Hoffman Estates, Illinois., Gutiérrez F; Department of Medicine, Division of Infectious Diseases, Centro de Investigación Biomédica en Red (CIBERINFEC), Hospital General de Elche & Universidad Miguel Hernández, Alicante, Spain., Estrada V; Hospital Clinico San Carlos, Ciber de Enfermedades Infecciosas, CIBERINFEC, Universidad Complutense de Madrid, Madrid, Spain., Burgos J; Department of Infectious Diseases, Hospital Universitario Vall d'Hebron, Barcelona, Spain., Boyles T; Clinical HIV Research Unit, Helen Joseph Hospital, Johannesburg, South Africa., Paño-Pardo JR; Department of Infectious Diseases, Hospital Clinico Universitario Lozano Blesa, Jaragoza, Spain., Hussen N; Department of Clinical Research, Worthwhile Clinical Trials (Lakeview Hospital), Benoni, South Africa., Rosenberg Y; National Heart, Lung, and Blood Institute, Bethesda, Maryland., Troendle J; National Heart, Lung, and Blood Institute, Bethesda, Maryland., Bernard GR; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Bistran-Hall AJ; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Walsh K; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Casey JD; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., DeClercq J; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee., Joly MM; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Pulley J; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Rice TW; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Schildcrout JS; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee., Wang L; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee., Semler MW; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Self WH; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee.
Corporate Authors: ACTIV-4 Host Tissue Investigators
Source: JAMA network open [JAMA Netw Open] 2024 Dec 02; Vol. 7 (12), pp. e2448215. Date of Electronic Publication: 2024 Dec 02.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2574-3805
DOI:10.1001/jamanetworkopen.2024.48215