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Programming tissue-sensing T cells that deliver therapies to the brain.

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Title: Programming tissue-sensing T cells that deliver therapies to the brain.
Authors: Simic MS; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Watchmaker PB; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA., Gupta S; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Wang Y; Department of Computer Science, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA., Sagan SA; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Duecker J; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Shepherd C; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Diebold D; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA., Pineo-Cavanaugh P; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA., Haegelin J; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA., Zhu R; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Ng B; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Yu W; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Tonai Y; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Cardarelli L; School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada., Reddy NR; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Sidhu SS; School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada., Troyanskaya O; Department of Computer Science, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.; Center for Computational Biology, Flatiron Institute, New York, NY, USA., Hauser SL; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Wilson MR; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Zamvil SS; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.; Program in Immunology, University of California San Francisco, San Francisco, CA, USA., Okada H; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; Helen Diller Cancer Center, University of California San Francisco, San Francisco, CA, USA., Lim WA; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.
Source: Science (New York, N.Y.) [Science] 2024 Dec 06; Vol. 386 (6726), pp. eadl4237. Date of Electronic Publication: 2024 Dec 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: Programming tissue-sensing T cells that deliver therapies to the brain.
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  Data: <searchLink fieldCode="AU" term="%22Simic+MS%22">Simic MS</searchLink>; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Watchmaker+PB%22">Watchmaker PB</searchLink>; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+S%22">Gupta S</searchLink>; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Computer Science, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Sagan+SA%22">Sagan SA</searchLink>; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Duecker+J%22">Duecker J</searchLink>; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shepherd+C%22">Shepherd C</searchLink>; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Diebold+D%22">Diebold D</searchLink>; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pineo-Cavanaugh+P%22">Pineo-Cavanaugh P</searchLink>; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Haegelin+J%22">Haegelin J</searchLink>; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+R%22">Zhu R</searchLink>; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ng+B%22">Ng B</searchLink>; 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School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Troyanskaya+O%22">Troyanskaya O</searchLink>; Department of Computer Science, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.; Center for Computational Biology, Flatiron Institute, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hauser+SL%22">Hauser SL</searchLink>; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+MR%22">Wilson MR</searchLink>; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zamvil+SS%22">Zamvil SS</searchLink>; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.; Program in Immunology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Okada+H%22">Okada H</searchLink>; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; Helen Diller Cancer Center, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lim+WA%22">Lim WA</searchLink>; UCSF Cell Design Institute and Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.
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