Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease.

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Title: Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease.
Authors: Hall PR; Department of Biochemistry, University of Oxford, Oxford, UK; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK; Scripps Institute, San Diego, CA, USA; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Jouen-Tachoire T; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK; Department of Pharmacology, University of Oxford, Oxford, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK., Schewe M; Institute of Physiology, Kiel University, Kiel, Germany., Proks P; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Baukrowitz T; Institute of Physiology, Kiel University, Kiel, Germany., Carpenter EP; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Newstead S; Department of Biochemistry, University of Oxford, Oxford, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Rödström KEJ; Department of Biochemistry, University of Oxford, Oxford, UK; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. Electronic address: karin.rodstrom@bioch.ox.ac.uk., Tucker SJ; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. Electronic address: stephen.tucker@physics.ox.ac.uk.
Source: Structure (London, England : 1993) [Structure] 2025 Jan 02; Vol. 33 (1), pp. 115-122.e4. Date of Electronic Publication: 2024 Dec 04.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1878-4186
DOI:10.1016/j.str.2024.11.005