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Novel loci and biomedical consequences of iron homoeostasis variation.

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Title: Novel loci and biomedical consequences of iron homoeostasis variation.
Authors: Allara E; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. ea431@medschl.cam.ac.uk.; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, Cambridge, UK. ea431@medschl.cam.ac.uk.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK. ea431@medschl.cam.ac.uk., Bell S; Precision Breast Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Centre, Li Ka Shing Centre, University of Cambridge, Cambridge, UK., Smith R; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Keene SJ; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Gill D; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Gaziano L; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Morselli Gysi D; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Department of Statistics, Federal University of Parana, Curitiba, Brazil.; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Wang F; Genetic Epidemiology Lab, Institute for Molecular Medicine Finland, Helsinki, Finland., Tragante V; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Mason A; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Karthikeyan S; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Lumbers RT; UCL Institute of Health Informatics, London, UK., Bonglack E; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK., Ouwehand W; Department of Haematology, University of Cambridge, Cambridge, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK.; Department of Haematology, University College London Hospitals NHS Trust, London, UK., Roberts DJ; Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.; Department of Haematology, Churchill Hospital, Headington, Oxford, UK., Dowsett J; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Larsen MH; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Pedersen OB; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Immunology, Zealand University Hospital, Køge, Denmark., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Banasik K; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Erikstrup C; Department of Immunology, Aarhus University Hospital, Aarhus, Denmark., Mitchell J; Eurac Research, Institute for Biomedicine, Bolzano, Italy., Fuchsberger C; Eurac Research, Institute for Biomedicine, Bolzano, Italy., Pattaro C; Eurac Research, Institute for Biomedicine, Bolzano, Italy., Pramstaller PP; Eurac Research, Institute for Biomedicine, Bolzano, Italy.; Department of Neurology, General Central Hospital, Bolzano, Italy., Girelli D; Department of Medicine, Section of Internal Medicine, EuroBloodNet Referral Center, University Hospital of Verona, Verona, Italy., Arvas M; Finnish Red Cross Blood Service, Helsinki, Finland., Toivonen J; Finnish Red Cross Blood Service, Helsinki, Finland., Molnos S; msg life central europe gmbh, München, Germany.; Institute of Epidemiology, Helmholtz Munich, Neuherberg, Germany., Peters A; Institute of Epidemiology, Helmholtz Munich, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, München, Germany., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Rudan I; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland, Edinburgh, UK., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., McDonnell C; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland, Edinburgh, UK.; Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK., Pirastu N; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland, Edinburgh, UK.; Genomics Research Centre, Human Technopole, Milan, Italy., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland, Edinburgh, UK.; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., van den Hurk K; Donor Studies, Department of Donor Medicine Research, Sanquin Research, Amsterdam, The Netherlands.; Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, The Netherlands., Quee F; Donor Studies, Department of Donor Medicine Research, Sanquin Research, Amsterdam, The Netherlands.; Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, The Netherlands., Ferrucci L; Longitudinal studies section, National Institute on Aging, Baltimore, MD, USA., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy., Tanaka T; Longitudinal studies section, National Institute on Aging, Baltimore, MD, USA., Girotto G; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Concas MP; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy., Pecori A; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Regeneron Genetics Center, Tarrytown, NY, USA., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands., van de Vegte YJ; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Kiemeney LA; IQ Health, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands., Sweep FC; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Galesloot TE; IQ Health, Radboud University Medical Center, Nijmegen, The Netherlands., Sulem P; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Gudbjartsson D; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Ferkingstad E; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Djousse L; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Cho K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Inouye M; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK.; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Burgess S; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK.; Medical Research Council Biostatistics Unit, Cambridge, UK., Benyamin B; Australian Centre for Precision Health & Allied Health and Human Performance, University of South Australia, Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., Oexle K; Neurogenetic Systems Analysis Group, Institute of Neurogenomics, Helmholtz Munich, Neuherberg, Germany.; Institute of Human Genetics, School of Medicine, Technical University of Munich, München, Germany., Swinkels D; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Sanquin Blood Bank, Amsterdam, The Netherlands., Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Magnusson M; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Ganna A; Genetic Epidemiology Lab, Institute for Molecular Medicine Finland, Helsinki, Finland., Gaziano M; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ivey K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Danesh J; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK., Pereira A; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Wood AM; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Cambridge Centre of Artificial Intelligence in Medicine, Cambridge, UK., Butterworth AS; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK., Di Angelantonio E; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. ed303@medschl.cam.ac.uk.; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, Cambridge, UK. ed303@medschl.cam.ac.uk.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK. ed303@medschl.cam.ac.uk.; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK. ed303@medschl.cam.ac.uk.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK. ed303@medschl.cam.ac.uk.; Health Data Science Centre, Human Technopole, Milan, Italy. ed303@medschl.cam.ac.uk.
Corporate Authors: DBDS Genomic Consortium, FinnGen Consortium
Source: Communications biology [Commun Biol] 2024 Dec 06; Vol. 7 (1), pp. 1631. Date of Electronic Publication: 2024 Dec 06.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2399-3642
DOI:10.1038/s42003-024-07115-3