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Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer.

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Title: Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer.
Authors: Gallego RA; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Cho-Schultz S; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Del Bel M; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Dechert-Schmitt AM; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States., Donaldson JS; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., He M; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Jalaie M; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Kania R; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Matthews J; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., McTigue M; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Tuttle JB; Worldwide Research and Development, Pfizer, Inc., Cambridge, Massachusetts 02139, United States., Risley H; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States., Zhou D; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States., Zhou R; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Ahmad OK; Worldwide Research and Development, Pfizer, Inc., Cambridge, Massachusetts 02139, United States., Bernier L; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Berritt S; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States., Braganza J; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Chen Z; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States., Cianfrogna JA; Pharmacokinetics, Dynamics and Metabolism Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Collins M; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Costa Jones C; Oncology Research Unit Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Cronin CN; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Davis C; Pharmacokinetics, Dynamics and Metabolism Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Dress K; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Edwards M; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Farrell W; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., France SP; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States., Grable N; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Johnson E; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Johnson TW; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Jones R; Pharmacokinetics, Dynamics and Metabolism Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Knauber T; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States., Lafontaine J; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Loach RP; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States., Maestre M; Oncology Research Unit Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Miller N; Oncology Research Unit Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Moen M; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States., Monfette S; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States., Morse P; Pharmacokinetics, Dynamics and Metabolism Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Nager AR; Oncology Research Unit Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Niosi M; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States., Richardson P; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Rohner AK; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Sach NW; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Timofeevski S; Oncology Research Unit Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States., Tucker JW; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States., Vetelino B; Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut 06340, United States., Zhang L; Worldwide Research and Development, Pfizer, Inc., Cambridge, Massachusetts 02139, United States., Nair SK; Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Dec 26; Vol. 67 (24), pp. 22002-22038. Date of Electronic Publication: 2024 Dec 09.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.4c01930