Discontinuation of First-Line Disease-Modifying Therapy in Patients With Stable Multiple Sclerosis: The DOT-MS Randomized Clinical Trial.
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| Title: | Discontinuation of First-Line Disease-Modifying Therapy in Patients With Stable Multiple Sclerosis: The DOT-MS Randomized Clinical Trial. |
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| Authors: | Coerver EME; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands., Fung WH; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands., de Beukelaar J; Neurology, Albert Schweitzer Hospital, Dordrecht, the Netherlands., Bouvy WH; Neurology, Diakonessenhuis, Utrecht, the Netherlands., Canta LR; Neurology, Catharina Hospital, Eindhoven, the Netherlands., Gerlach OHH; Neurology, Zuyderland Medical Center, Sittard-Geleen, the Netherlands.; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands., Hoitsma E; Neurology, Alrijne Hospital, Leiden, the Netherlands., Hoogervorst ELJ; Neurology, St Antonius Hospital, Utrecht, the Netherlands., de Jong BA; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands., Kalkers NF; Neurology, OLVG, Amsterdam, the Netherlands., van Kempen ZLE; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands., Lövenich H; Neurology, St Jans Gasthuis, Weert, the Netherlands., van Munster CEP; Neurology, Amphia Hospital, Breda, the Netherlands., van Oosten BW; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands., Smolders J; MS Center ErasMS, Neurology & Immunology, Erasmus Medical Center, Rotterdam, the Netherlands., Vennegoor A; Neurology, Flevoziekenhuis, Almere, the Netherlands., Zeinstra EMPE; Neurology, Isala Hospital, Meppel, the Netherlands., Barrantes-Cepas M; MS Center Amsterdam, Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam University Medical Center, location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Kooij G; MS Center Amsterdam, Molecular Cell Biology and Immunology, Amsterdam Neuroscience, Amsterdam University Medical Center, location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Schoonheim MM; MS Center Amsterdam, Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam University Medical Center, location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Lissenberg-Witte BI; Department of Epidemiology and Data Science, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Teunissen CE; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Moraal B; MS Center Amsterdam, Radiology & Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Barkhof F; MS Center Amsterdam, Radiology & Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, London, United Kingdom., Uitdehaag BMJ; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands., Mostert J; Neurology, Rijnstate Hospital, Arnhem, the Netherlands., Killestein J; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands., Strijbis EMM; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands. |
| Source: | JAMA neurology [JAMA Neurol] 2025 Feb 01; Vol. 82 (2), pp. 123-131. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Multicenter Study; Equivalence Trial |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2168-6157 |
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| DOI: | 10.1001/jamaneurol.2024.4164 |
