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Discontinuation of First-Line Disease-Modifying Therapy in Patients With Stable Multiple Sclerosis: The DOT-MS Randomized Clinical Trial.

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Title: Discontinuation of First-Line Disease-Modifying Therapy in Patients With Stable Multiple Sclerosis: The DOT-MS Randomized Clinical Trial.
Authors: Coerver EME; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands., Fung WH; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands., de Beukelaar J; Neurology, Albert Schweitzer Hospital, Dordrecht, the Netherlands., Bouvy WH; Neurology, Diakonessenhuis, Utrecht, the Netherlands., Canta LR; Neurology, Catharina Hospital, Eindhoven, the Netherlands., Gerlach OHH; Neurology, Zuyderland Medical Center, Sittard-Geleen, the Netherlands.; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands., Hoitsma E; Neurology, Alrijne Hospital, Leiden, the Netherlands., Hoogervorst ELJ; Neurology, St Antonius Hospital, Utrecht, the Netherlands., de Jong BA; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands., Kalkers NF; Neurology, OLVG, Amsterdam, the Netherlands., van Kempen ZLE; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands., Lövenich H; Neurology, St Jans Gasthuis, Weert, the Netherlands., van Munster CEP; Neurology, Amphia Hospital, Breda, the Netherlands., van Oosten BW; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands., Smolders J; MS Center ErasMS, Neurology & Immunology, Erasmus Medical Center, Rotterdam, the Netherlands., Vennegoor A; Neurology, Flevoziekenhuis, Almere, the Netherlands., Zeinstra EMPE; Neurology, Isala Hospital, Meppel, the Netherlands., Barrantes-Cepas M; MS Center Amsterdam, Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam University Medical Center, location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Kooij G; MS Center Amsterdam, Molecular Cell Biology and Immunology, Amsterdam Neuroscience, Amsterdam University Medical Center, location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Schoonheim MM; MS Center Amsterdam, Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam University Medical Center, location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Lissenberg-Witte BI; Department of Epidemiology and Data Science, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Teunissen CE; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Moraal B; MS Center Amsterdam, Radiology & Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Barkhof F; MS Center Amsterdam, Radiology & Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, London, United Kingdom., Uitdehaag BMJ; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands., Mostert J; Neurology, Rijnstate Hospital, Arnhem, the Netherlands., Killestein J; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands., Strijbis EMM; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands.
Source: JAMA neurology [JAMA Neurol] 2025 Feb 01; Vol. 82 (2), pp. 123-131.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Equivalence Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discontinuation of First-Line Disease-Modifying Therapy in Patients With Stable Multiple Sclerosis: The DOT-MS Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Coerver+EME%22">Coerver EME</searchLink>; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Fung+WH%22">Fung WH</searchLink>; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Beukelaar+J%22">de Beukelaar J</searchLink>; Neurology, Albert Schweitzer Hospital, Dordrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bouvy+WH%22">Bouvy WH</searchLink>; Neurology, Diakonessenhuis, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Canta+LR%22">Canta LR</searchLink>; Neurology, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gerlach+OHH%22">Gerlach OHH</searchLink>; Neurology, Zuyderland Medical Center, Sittard-Geleen, the Netherlands.; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hoitsma+E%22">Hoitsma E</searchLink>; Neurology, Alrijne Hospital, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hoogervorst+ELJ%22">Hoogervorst ELJ</searchLink>; Neurology, St Antonius Hospital, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Jong+BA%22">de Jong BA</searchLink>; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kalkers+NF%22">Kalkers NF</searchLink>; Neurology, OLVG, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Kempen+ZLE%22">van Kempen ZLE</searchLink>; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lövenich+H%22">Lövenich H</searchLink>; Neurology, St Jans Gasthuis, Weert, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Munster+CEP%22">van Munster CEP</searchLink>; Neurology, Amphia Hospital, Breda, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Oosten+BW%22">van Oosten BW</searchLink>; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Smolders+J%22">Smolders J</searchLink>; MS Center ErasMS, Neurology & Immunology, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vennegoor+A%22">Vennegoor A</searchLink>; Neurology, Flevoziekenhuis, Almere, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zeinstra+EMPE%22">Zeinstra EMPE</searchLink>; Neurology, Isala Hospital, Meppel, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Barrantes-Cepas+M%22">Barrantes-Cepas M</searchLink>; MS Center Amsterdam, Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam University Medical Center, location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kooij+G%22">Kooij G</searchLink>; MS Center Amsterdam, Molecular Cell Biology and Immunology, Amsterdam Neuroscience, Amsterdam University Medical Center, location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Schoonheim+MM%22">Schoonheim MM</searchLink>; MS Center Amsterdam, Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam University Medical Center, location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lissenberg-Witte+BI%22">Lissenberg-Witte BI</searchLink>; Department of Epidemiology and Data Science, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Teunissen+CE%22">Teunissen CE</searchLink>; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Moraal+B%22">Moraal B</searchLink>; MS Center Amsterdam, Radiology & Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Barkhof+F%22">Barkhof F</searchLink>; MS Center Amsterdam, Radiology & Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Uitdehaag+BMJ%22">Uitdehaag BMJ</searchLink>; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mostert+J%22">Mostert J</searchLink>; Neurology, Rijnstate Hospital, Arnhem, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Killestein+J%22">Killestein J</searchLink>; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Strijbis+EMM%22">Strijbis EMM</searchLink>; Multiple Sclerosis Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center location VUmc, Amsterdam, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101589536%22">JAMA neurology</searchLink> [JAMA Neurol] 2025 Feb 01; Vol. 82 (2), pp. 123-131.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Medical+Association%22">American Medical Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101589536 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2168-6157 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221686149%22">21686149 </searchLink><i>NLM ISO Abbreviation: </i>JAMA Neurol <i>Subsets: </i>MEDLINE
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