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A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.

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Title: A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.
Authors: Xie SC; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.; Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Tai CW; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia., Morton CJ; Biomedical Manufacturing Program, CSIRO, Clayton South, Victoria, Australia., Ma L; Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America., Huang SC; Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America., Wittlin S; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland., Du Y; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia., Hu Y; Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America., Dogovski C; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia., Salimimarand M; School of Chemistry, The University of Melbourne, Melbourne, Victoria, Australia., Griffin R; Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America., England D; Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America., de la Cruz E; Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America., Deni I; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, New York, United States of America.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America., Yeo T; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, New York, United States of America.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America., Burkhard AY; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, New York, United States of America.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America., Striepen J; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, New York, United States of America.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America., Schindler KA; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, New York, United States of America.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America., Crespo B; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Gamo FJ; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain., Khandokar Y; ANSTO-Australian Synchrotron, Clayton, Victoria, Australia., Hutton CA; School of Chemistry, The University of Melbourne, Melbourne, Victoria, Australia., Rabie T; Department of Biochemistry, Genetics and Microbiology, University of Pretoria Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, South Africa., Birkholtz LM; Department of Biochemistry, Genetics and Microbiology, University of Pretoria Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, South Africa., Famodimu MT; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom., Delves MJ; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom., Bolsher J; TropIQ Health Sciences, Nijmegen, The Netherlands., Koolen KMJ; TropIQ Health Sciences, Nijmegen, The Netherlands., van der Laak R; TropIQ Health Sciences, Nijmegen, The Netherlands., Aguiar ACC; Federal University of São Paulo, São Paulo, São Paulo, Brazil., Pereira DB; Research Center for Tropical Medicine of Rondonia, Porto Velho, Brazil., Guido RVC; Sao Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil., Creek DJ; Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Fidock DA; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, New York, United States of America.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America.; Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, United States of America., Dick LR; Seofon Consulting, Natick, Massachusetts, United States of America., Brand SL; Medicines for Malaria Venture, Geneva, Switzerland., Gould AE; Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America., Langston S; Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America., Griffin MDW; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia., Tilley L; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.
Source: PLoS pathogens [PLoS Pathog] 2024 Dec 09; Vol. 20 (12), pp. e1012429. Date of Electronic Publication: 2024 Dec 09 (Print Publication: 2024).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.
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Federal University of São Paulo, São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Pereira+DB%22">Pereira DB</searchLink>; Research Center for Tropical Medicine of Rondonia, Porto Velho, Brazil.<br /><searchLink fieldCode="AU" term="%22Guido+RVC%22">Guido RVC</searchLink>; Sao Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.<br /><searchLink fieldCode="AU" term="%22Creek+DJ%22">Creek DJ</searchLink>; Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Fidock+DA%22">Fidock DA</searchLink>; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, New York, United States of America.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America.; Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Dick+LR%22">Dick LR</searchLink>; 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