A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures.

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Title: A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures.
Authors: Rifkin RA; Department of Neurology, Columbia University Irving Medical Center, 710 West 168th Street, New York, NY, 10032-3784, USA. Electronic address: rr3302@cumc.columbia.edu., Wu X; Department of Neurological Surgery, Columbia University Irving Medical Center, 710 West 168th Street, New York, NY, 10032-3784, USA. Electronic address: xw2013@cumc.columbia.edu., Pereira B; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, 630 West 168th Street, Mailbox 23, New York, NY, 10032, USA. Electronic address: bp2401@cumc.columbia.edu., Gill BJ; Department of Neurological Surgery, Columbia University Irving Medical Center, 710 West 168th Street, New York, NY, 10032-3784, USA. Electronic address: bjg2140@cumc.columbia.edu., Merricks EM; Department of Neurology, Columbia University Irving Medical Center, 710 West 168th Street, New York, NY, 10032-3784, USA. Electronic address: em3217@cumc.columbia.edu., Michalak AJ; Department of Neurology, New York University Grossman School of Medicine, 222 East 41st Street, 14th Floor New York, NY, 10017, USA. Electronic address: andrew.michalak@nyulangone.org., Goldberg AR; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, 630 West 168th Street, Mailbox 23, New York, NY, 10032, USA. Electronic address: ag3311@cumc.columbia.edu., Humala N; Department of Neurological Surgery, Columbia University Irving Medical Center, 710 West 168th Street, New York, NY, 10032-3784, USA. Electronic address: nh2560@cumc.columbia.edu., Dovas A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, 630 West 168th Street, Mailbox 23, New York, NY, 10032, USA. Electronic address: ad3106@cumc.columbia.edu., Rai G; National Center for Advancing Translational Sciences, National Institutes of Health, 9609 Medical Center Drive, Rockville, MD, 20850-9793, USA. Electronic address: bantukallug@mail.nih.gov., McKhann GM; Department of Neurological Surgery, Columbia University Irving Medical Center, 710 West 168th Street, New York, NY, 10032-3784, USA. Electronic address: gm317@cumc.columbia.edu., Slesinger PA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029-5674, USA. Electronic address: Paul.Slesinger@mssm.edu., Canoll P; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, 630 West 168th Street, Mailbox 23, New York, NY, 10032, USA. Electronic address: pc561@cumc.columbia.edu., Schevon C; Department of Neurology, Columbia University Irving Medical Center, 710 West 168th Street, New York, NY, 10032-3784, USA. Electronic address: cas2044@cumc.columbia.edu.
Source: Neuropharmacology [Neuropharmacology] 2025 Mar 01; Vol. 265, pp. 110259. Date of Electronic Publication: 2024 Dec 09.
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-7064
DOI:10.1016/j.neuropharm.2024.110259