Hydrophobic ion pairing: lipophilicity improvement of anionic macromolecules by divalent cation mediated complex formation.

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Title: Hydrophobic ion pairing: lipophilicity improvement of anionic macromolecules by divalent cation mediated complex formation.
Authors: Lindner S; Thiomatrix Forschungs- Und Beratungs GmbH, Trientlgasse 65, 6020, Innsbruck, Austria., Ricci F; Thiomatrix Forschungs- Und Beratungs GmbH, Trientlgasse 65, 6020, Innsbruck, Austria., Holm R; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230, Odense, Denmark., Sun D; Pharmaceutical Product Development & Supply, Johnson & Johnson Innovative Medicine, Turnhoutseweg 30, B-2340, Beerse, Belgium., Washburn N; Immunology Discovery, Johnson & Johnson Innovative Medicine, 301 Binney St, Cambridge, MA, 02141, USA., Michalowski CB; Pharmaceutical Product Development & Supply, Johnson & Johnson Innovative Medicine, Turnhoutseweg 30, B-2340, Beerse, Belgium., Di Pretoro G; Drug Product Development & Delivery, Johnson & Johnson Innovative Medicine, 347 Phoenixville Pike, Malvern, PA, 19355, USA., Bernkop-Schnürch A; Thiomatrix Forschungs- Und Beratungs GmbH, Trientlgasse 65, 6020, Innsbruck, Austria. a.bernkop@thiomatrix.com.
Source: Drug delivery and translational research [Drug Deliv Transl Res] 2025 Aug; Vol. 15 (8), pp. 2676-2693. Date of Electronic Publication: 2024 Dec 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2190-3948
DOI:10.1007/s13346-024-01760-1