Absorption, single-dose and steady-state metabolism, excretion, and pharmacokinetics of adagrasib, a KRASG12C inhibitor.
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| Title: | Absorption, single-dose and steady-state metabolism, excretion, and pharmacokinetics of adagrasib, a KRASG12C inhibitor. |
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| Authors: | Rahbaek L; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA. Lisa.rahbaek@gmail.com., Cilliers C; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA., Wegerski CJ; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA.; DMPK, Atomwise Inc,, San Francisco, CA, USA., Nguyen N; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA., Otten J; Array Biopharma Inc., Boulder, CA, USA.; ADME/DMPK, Loxo@Lilly Inc., Boulder, CA, USA., Hargis L; Mirati Therapeutics Inc., San Diego, CA, USA.; Department of Chemistry, The Scripps Research Institute, San Diego, CA, USA., Marx MA; Drug Discovery, Mirati Therapeutics Inc., San Diego, CA, USA., Christensen JG; Mirati Therapeutics Inc., San Diego, CA, USA., Tran JQ; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA. |
| Source: | Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2024 Dec 19; Vol. 95 (1), pp. 7. Date of Electronic Publication: 2024 Dec 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39699634 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Absorption, single-dose and steady-state metabolism, excretion, and pharmacokinetics of adagrasib, a KRAS<superscript>G12C</superscript> inhibitor. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Rahbaek+L%22">Rahbaek L</searchLink>; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA. Lisa.rahbaek@gmail.com.<br /><searchLink fieldCode="AU" term="%22Cilliers+C%22">Cilliers C</searchLink>; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wegerski+CJ%22">Wegerski CJ</searchLink>; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA.; DMPK, Atomwise Inc,, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+N%22">Nguyen N</searchLink>; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Otten+J%22">Otten J</searchLink>; Array Biopharma Inc., Boulder, CA, USA.; ADME/DMPK, Loxo@Lilly Inc., Boulder, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hargis+L%22">Hargis L</searchLink>; Mirati Therapeutics Inc., San Diego, CA, USA.; Department of Chemistry, The Scripps Research Institute, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Marx+MA%22">Marx MA</searchLink>; Drug Discovery, Mirati Therapeutics Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Christensen+JG%22">Christensen JG</searchLink>; Mirati Therapeutics Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tran+JQ%22">Tran JQ</searchLink>; Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc., San Diego, CA, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227806519%22">Cancer chemotherapy and pharmacology</searchLink> [Cancer Chemother Pharmacol] 2024 Dec 19; Vol. 95 (1), pp. 7. <i>Date of Electronic Publication: </i>2024 Dec 19. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>7806519 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0843 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203445704%22">03445704 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Chemother Pharmacol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39699634 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00280-024-04728-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 7 Titles: – TitleFull: Absorption, single-dose and steady-state metabolism, excretion, and pharmacokinetics of adagrasib, a KRASG12C inhibitor. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rahbaek L – PersonEntity: Name: NameFull: Cilliers C – PersonEntity: Name: NameFull: Wegerski CJ – PersonEntity: Name: NameFull: Nguyen N – PersonEntity: Name: NameFull: Otten J – PersonEntity: Name: NameFull: Hargis L – PersonEntity: Name: NameFull: Marx MA – PersonEntity: Name: NameFull: Christensen JG – PersonEntity: Name: NameFull: Tran JQ IsPartOfRelationships: – BibEntity: Dates: – D: 19 M: 12 Text: 2024 Dec 19 Type: published Y: 2024 Identifiers: – Type: issn-electronic Value: 1432-0843 Numbering: – Type: volume Value: 95 – Type: issue Value: 1 Titles: – TitleFull: Cancer chemotherapy and pharmacology Type: main |
| ResultId | 1 |
