TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis.

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Title: TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis.
Authors: Loos B; University of Zürich, Institute of Anatomy, Winterthurerstrasse 190, 8057, Zürich, Switzerland., Salas-Bastos A; University of Zürich, Institute of Anatomy, Winterthurerstrasse 190, 8057, Zürich, Switzerland., Nordin A; Wallenberg Centre for Molecular Medicine, Linköping University, 58185, Linköping, Sweden.; Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology; Faculty of Medicine and Health Sciences, Linköping University, 58185, Linköping, Sweden., Debbache J; University of Zürich, Institute of Anatomy, Winterthurerstrasse 190, 8057, Zürich, Switzerland., Stierli S; University of Zürich, Institute of Anatomy, Winterthurerstrasse 190, 8057, Zürich, Switzerland., Cheng PF; University of Zürich Hospital, University of Zürich, Department of Dermatology, Raemistrasse 100, 8091, Zürich, Switzerland., Rufli S; University of Zurich, Institute of Experimental Immunology, Winterthurerstrasse 190, 8057, Zürich, Switzerland., Wyss C; University of Zürich Hospital, University of Zürich, Department of Dermatology, Raemistrasse 100, 8091, Zürich, Switzerland., Levesque MP; University of Zürich Hospital, University of Zürich, Department of Dermatology, Raemistrasse 100, 8091, Zürich, Switzerland., Dummer R; University of Zürich Hospital, University of Zürich, Department of Dermatology, Raemistrasse 100, 8091, Zürich, Switzerland., Wong WW; University of Zurich, Institute of Experimental Immunology, Winterthurerstrasse 190, 8057, Zürich, Switzerland.; Department of Molecular Life Sciences, University of Zürich, Zürich, Switzerland., Pascolo S; University of Zürich Hospital, University of Zürich, Department of Dermatology, Raemistrasse 100, 8091, Zürich, Switzerland.; Faculty of Medicine, University of Zürich, Zürich, Switzerland., Cantù C; Wallenberg Centre for Molecular Medicine, Linköping University, 58185, Linköping, Sweden.; Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology; Faculty of Medicine and Health Sciences, Linköping University, 58185, Linköping, Sweden., Sommer L; University of Zürich, Institute of Anatomy, Winterthurerstrasse 190, 8057, Zürich, Switzerland. lukas.sommer@anatomy.uzh.ch.
Source: Cell death & disease [Cell Death Dis] 2024 Dec 21; Vol. 15 (12), pp. 925. Date of Electronic Publication: 2024 Dec 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-024-07305-1