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Sulfonamide-Pyrazole derivatives as next-generation Cyclooxygenase-2 enzyme inhibitors: From molecular design to in vivo efficacy.

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Title: Sulfonamide-Pyrazole derivatives as next-generation Cyclooxygenase-2 enzyme inhibitors: From molecular design to in vivo efficacy.
Authors: Elgohary MK; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Cairo 11829, Egypt. Electronic address: mohamed-elgohary@eru.edu.eg., Elkotamy MS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Cairo 11829, Egypt., Alkabbani MA; Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Cairo 11829, Egypt., El Hassab MA; Department of Medicinal Chemistry, Faculty of Pharmacy, King Salman International University (KSIU), South Sinai, Egypt., Al-Rashood ST; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia., Binjubair FA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia., Alsulaimany M; Department of Pharmacognosy & Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Medina 42353, Saudi Arabia., Ghabbour HA; School of Health and Biomedical Sciences, RMIT University, Melbourne 3083, Australia., Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, P.O. Box 33516, Egypt., Abdel-Aziz HA; Applied Organic Chemistry Department, National Research Center, Dokki, Cairo 12622, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia St., Alexandria 21648, Egypt. Electronic address: hatem_741@yahoo.com.
Source: International journal of biological macromolecules [Int J Biol Macromol] 2025 Mar; Vol. 293, pp. 139170. Date of Electronic Publication: 2024 Dec 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sulfonamide-Pyrazole derivatives as next-generation Cyclooxygenase-2 enzyme inhibitors: From molecular design to in vivo efficacy.
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  Data: <searchLink fieldCode="AU" term="%22Elgohary+MK%22">Elgohary MK</searchLink>; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Cairo 11829, Egypt. Electronic address: mohamed-elgohary@eru.edu.eg.<br /><searchLink fieldCode="AU" term="%22Elkotamy+MS%22">Elkotamy MS</searchLink>; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Cairo 11829, Egypt.<br /><searchLink fieldCode="AU" term="%22Alkabbani+MA%22">Alkabbani MA</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Cairo 11829, Egypt.<br /><searchLink fieldCode="AU" term="%22El+Hassab+MA%22">El Hassab MA</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, King Salman International University (KSIU), South Sinai, Egypt.<br /><searchLink fieldCode="AU" term="%22Al-Rashood+ST%22">Al-Rashood ST</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Binjubair+FA%22">Binjubair FA</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alsulaimany+M%22">Alsulaimany M</searchLink>; Department of Pharmacognosy & Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Medina 42353, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ghabbour+HA%22">Ghabbour HA</searchLink>; School of Health and Biomedical Sciences, RMIT University, Melbourne 3083, Australia.<br /><searchLink fieldCode="AU" term="%22Eldehna+WM%22">Eldehna WM</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, P.O. Box 33516, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdel-Aziz+HA%22">Abdel-Aziz HA</searchLink>; Applied Organic Chemistry Department, National Research Center, Dokki, Cairo 12622, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia St., Alexandria 21648, Egypt. Electronic address: hatem_741@yahoo.com.
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  Data: <searchLink fieldCode="JN" term="%227909578%22">International journal of biological macromolecules</searchLink> [Int J Biol Macromol] 2025 Mar; Vol. 293, pp. 139170. <i>Date of Electronic Publication: </i>2024 Dec 28.
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              Text: 2025 Mar
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