Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.
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| Title: | Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease. |
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| Authors: | Li Z; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Gu M; Section of Pulmonary/Critical Care and Allergy/Immunology, Department of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA.; International Flavors and Fragrances Health and Bioscience, Shanghai, China., Zaparte A; Section of Pulmonary/Critical Care and Allergy/Immunology, Department of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA.; Comprehensive Alcohol Research Center, School of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA., Fu X; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Center for Microbiome and Human Health, Learner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Mahen K; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Center for Microbiome and Human Health, Learner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Northern Ohio Alcohol Center (NOAC), Cleveland Clinic, Cleveland, OH, USA., Mrdjen M; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Center for Microbiome and Human Health, Learner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Northern Ohio Alcohol Center (NOAC), Cleveland Clinic, Cleveland, OH, USA., Li XS; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Center for Microbiome and Human Health, Learner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Yang Z; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Ma J; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Thoudam T; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Chandler K; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Hesler M; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Heathers L; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Gorse K; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Van TT; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Wong D; Integrative Biology and Physiology, University of California, Los Angeles, CA, USA., Gibson AM; The Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Wang Z; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Taylor CM; Comprehensive Alcohol Research Center, School of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA.; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Science Center, New Orleans, LA, USA., Quijada P; Integrative Biology and Physiology, University of California, Los Angeles, CA, USA., Makarewich CA; The Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Hazen SL; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Center for Microbiome and Human Health, Learner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Heart and Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA., Liangpunsakul S; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.; Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA., Brown JM; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Center for Microbiome and Human Health, Learner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Northern Ohio Alcohol Center (NOAC), Cleveland Clinic, Cleveland, OH, USA., Lefer DJ; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Welsh DA; Section of Pulmonary/Critical Care and Allergy/Immunology, Department of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA.; Comprehensive Alcohol Research Center, School of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA., Sharp TE 3rd; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. tesharp@usf.edu.; Heart Institute, Morsani College of Medicine, USF Health, University South Florida, Tampa, FL, USA. tesharp@usf.edu. |
| Source: | Nature communications [Nat Commun] 2024 Dec 30; Vol. 15 (1), pp. 10788. Date of Electronic Publication: 2024 Dec 30. |
| Publication Type: | Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-55084-2 |
