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Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.

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Title: Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.
Authors: Li Z; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Gu M; Section of Pulmonary/Critical Care and Allergy/Immunology, Department of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA.; International Flavors and Fragrances Health and Bioscience, Shanghai, China., Zaparte A; Section of Pulmonary/Critical Care and Allergy/Immunology, Department of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA.; Comprehensive Alcohol Research Center, School of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA., Fu X; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Center for Microbiome and Human Health, Learner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Mahen K; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Center for Microbiome and Human Health, Learner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Northern Ohio Alcohol Center (NOAC), Cleveland Clinic, Cleveland, OH, USA., Mrdjen M; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Center for Microbiome and Human Health, Learner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Northern Ohio Alcohol Center (NOAC), Cleveland Clinic, Cleveland, OH, USA., Li XS; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Center for Microbiome and Human Health, Learner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Yang Z; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Ma J; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Thoudam T; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Chandler K; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Hesler M; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Heathers L; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Gorse K; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Van TT; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Wong D; Integrative Biology and Physiology, University of California, Los Angeles, CA, USA., Gibson AM; The Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Wang Z; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Taylor CM; Comprehensive Alcohol Research Center, School of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA.; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Science Center, New Orleans, LA, USA., Quijada P; Integrative Biology and Physiology, University of California, Los Angeles, CA, USA., Makarewich CA; The Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Hazen SL; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Center for Microbiome and Human Health, Learner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Heart and Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA., Liangpunsakul S; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.; Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA., Brown JM; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Center for Microbiome and Human Health, Learner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Northern Ohio Alcohol Center (NOAC), Cleveland Clinic, Cleveland, OH, USA., Lefer DJ; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Welsh DA; Section of Pulmonary/Critical Care and Allergy/Immunology, Department of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA.; Comprehensive Alcohol Research Center, School of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA., Sharp TE 3rd; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. tesharp@usf.edu.; Heart Institute, Morsani College of Medicine, USF Health, University South Florida, Tampa, FL, USA. tesharp@usf.edu.
Source: Nature communications [Nat Commun] 2024 Dec 30; Vol. 15 (1), pp. 10788. Date of Electronic Publication: 2024 Dec 30.
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.
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  Data: <searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gu+M%22">Gu M</searchLink>; Section of Pulmonary/Critical Care and Allergy/Immunology, Department of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA.; International Flavors and Fragrances Health and Bioscience, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zaparte+A%22">Zaparte A</searchLink>; Section of Pulmonary/Critical Care and Allergy/Immunology, Department of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA.; Comprehensive Alcohol Research Center, School of Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Fu+X%22">Fu X</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; 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Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Center for Microbiome and Human Health, Learner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Heart and Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Liangpunsakul+S%22">Liangpunsakul S</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.; Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Brown+JM%22">Brown JM</searchLink>; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Center for Microbiome and Human Health, Learner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; 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