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Quality by Design in continuous bioprocessing: Investigating the impact of critical process parameters of multi-column chromatography during steady-state and transient phases.

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Title: Quality by Design in continuous bioprocessing: Investigating the impact of critical process parameters of multi-column chromatography during steady-state and transient phases.
Authors: Zheng ZY; Downstream Processing, Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Centros #06-01 138668, Singapore., Chen AG; BiosanaProcess Pte. Ltd., 20 Biopolis Way, Centros #05-01 138668, Singapore., Dzulkiflie N; Downstream Processing, Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Centros #06-01 138668, Singapore., Sim LC; GlycoAnalytics, Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Centros #06-01 138668, Singapore., Tang WQ; Animal Cell Bioprocessing, Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Centros #06-01 138668, Singapore., Leong J; Animal Cell Bioprocessing, Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Centros #06-01 138668, Singapore., Ler WX; Animal Cell Bioprocessing, Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Centros #06-01 138668, Singapore., Leong D; Animal Cell Bioprocessing, Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Centros #06-01 138668, Singapore., Chng J; BiosanaProcess Pte. Ltd., 20 Biopolis Way, Centros #05-01 138668, Singapore., Manan NBA; BiosanaProcess Pte. Ltd., 20 Biopolis Way, Centros #05-01 138668, Singapore., Walsh I; GlycoAnalytics, Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Centros #06-01 138668, Singapore., Ng SK; Animal Cell Bioprocessing, Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Centros #06-01 138668, Singapore., Pennings M; BiosanaPharma, Bargelaan 200, 2333 CW Leiden, The Netherlands. Electronic address: maarten.pennings@2process.nl., Zhang W; Downstream Processing, Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Centros #06-01 138668, Singapore. Electronic address: zhang_wei@bti.a-star.edu.sg.
Source: Journal of chromatography. A [J Chromatogr A] 2025 Feb 08; Vol. 1742, pp. 465649. Date of Electronic Publication: 2024 Dec 31.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-3778
DOI:10.1016/j.chroma.2024.465649