Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice.
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| Title: | Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice. |
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| Authors: | Halfmann PJ; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA., Patel RS; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Loeffler K; School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Yasuhara A; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Van De Velde LA; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Yang JE; Department of Biochemistry, University of Wisconsin, Madison, WI, USA.; Department of Biochemistry, Cryo-EM Research Center, University of Wisconsin, Madison, WI, USA.; Department of Biochemistry, Midwest Center for Cryo-Electron Tomography, University of Wisconsin, Madison, WI, USA., Chervin J; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Troxell C; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Huang M; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Zheng N; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Wright ER; Department of Biochemistry, University of Wisconsin, Madison, WI, USA.; Department of Biochemistry, Cryo-EM Research Center, University of Wisconsin, Madison, WI, USA.; Department of Biochemistry, Midwest Center for Cryo-Electron Tomography, University of Wisconsin, Madison, WI, USA., Thomas PG; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wilson PC; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Kawaoka Y; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA. yoshihiro.kawaoka@wisc.edu.; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu.; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu.; Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), University of Tokyo, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu., Kane RS; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA. ravi.kane@chbe.gatech.edu.; School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA. ravi.kane@chbe.gatech.edu. |
| Source: | Nature communications [Nat Commun] 2025 Jan 07; Vol. 16 (1), pp. 462. Date of Electronic Publication: 2025 Jan 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-55824-y |
