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Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice.

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Title: Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice.
Authors: Halfmann PJ; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA., Patel RS; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Loeffler K; School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Yasuhara A; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Van De Velde LA; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Yang JE; Department of Biochemistry, University of Wisconsin, Madison, WI, USA.; Department of Biochemistry, Cryo-EM Research Center, University of Wisconsin, Madison, WI, USA.; Department of Biochemistry, Midwest Center for Cryo-Electron Tomography, University of Wisconsin, Madison, WI, USA., Chervin J; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Troxell C; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Huang M; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Zheng N; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Wright ER; Department of Biochemistry, University of Wisconsin, Madison, WI, USA.; Department of Biochemistry, Cryo-EM Research Center, University of Wisconsin, Madison, WI, USA.; Department of Biochemistry, Midwest Center for Cryo-Electron Tomography, University of Wisconsin, Madison, WI, USA., Thomas PG; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wilson PC; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Kawaoka Y; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA. yoshihiro.kawaoka@wisc.edu.; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu.; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu.; Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), University of Tokyo, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu., Kane RS; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA. ravi.kane@chbe.gatech.edu.; School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA. ravi.kane@chbe.gatech.edu.
Source: Nature communications [Nat Commun] 2025 Jan 07; Vol. 16 (1), pp. 462. Date of Electronic Publication: 2025 Jan 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice.
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  Data: <searchLink fieldCode="AU" term="%22Halfmann+PJ%22">Halfmann PJ</searchLink>; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Patel+RS%22">Patel RS</searchLink>; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Loeffler+K%22">Loeffler K</searchLink>; School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Yasuhara+A%22">Yasuhara A</searchLink>; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Van+De+Velde+LA%22">Van De Velde LA</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Yang+JE%22">Yang JE</searchLink>; Department of Biochemistry, University of Wisconsin, Madison, WI, USA.; Department of Biochemistry, Cryo-EM Research Center, University of Wisconsin, Madison, WI, USA.; Department of Biochemistry, Midwest Center for Cryo-Electron Tomography, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Chervin+J%22">Chervin J</searchLink>; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Troxell+C%22">Troxell C</searchLink>; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Huang+M%22">Huang M</searchLink>; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+N%22">Zheng N</searchLink>; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wright+ER%22">Wright ER</searchLink>; Department of Biochemistry, University of Wisconsin, Madison, WI, USA.; Department of Biochemistry, Cryo-EM Research Center, University of Wisconsin, Madison, WI, USA.; Department of Biochemistry, Midwest Center for Cryo-Electron Tomography, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+PG%22">Thomas PG</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+PC%22">Wilson PC</searchLink>; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kawaoka+Y%22">Kawaoka Y</searchLink>; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA. yoshihiro.kawaoka@wisc.edu.; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu.; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu.; Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), University of Tokyo, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu.<br /><searchLink fieldCode="AU" term="%22Kane+RS%22">Kane RS</searchLink>; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA. ravi.kane@chbe.gatech.edu.; School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA. ravi.kane@chbe.gatech.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Jan 07; Vol. 16 (1), pp. 462. <i>Date of Electronic Publication: </i>2025 Jan 07.
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