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Discovery of highly active kynureninases for cancer immunotherapy through protein language model.

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Title: Discovery of highly active kynureninases for cancer immunotherapy through protein language model.
Authors: Eom H; Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea., Park S; School of Biological Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea., Cho KS; Galux Inc, 1837 Nambusunhwan-ro, Gwanak-gu, Seoul 08738, Republic of Korea., Lee J; Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea., Kim H; School of Biological Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea., Kim S; School of Biological Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea., Yang J; Galux Inc, 1837 Nambusunhwan-ro, Gwanak-gu, Seoul 08738, Republic of Korea., Han YH; Galux Inc, 1837 Nambusunhwan-ro, Gwanak-gu, Seoul 08738, Republic of Korea., Lee J; Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.; School of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.; Arontier Co., 241 Gangnam-daero, Seocho-gu, Seoul 06735, Republic of Korea., Seok C; Artificial Intelligence Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.; Institute of Molecular Biology and Genetics, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.; Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.; Galux Inc, 1837 Nambusunhwan-ro, Gwanak-gu, Seoul 08738, Republic of Korea., Lee MS; Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.; Galux Inc, 1837 Nambusunhwan-ro, Gwanak-gu, Seoul 08738, Republic of Korea., Song WJ; Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea., Steinegger M; School of Biological Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.; Artificial Intelligence Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.; Institute of Molecular Biology and Genetics, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
Source: Nucleic acids research [Nucleic Acids Res] 2025 Jan 07; Vol. 53 (1).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of highly active kynureninases for cancer immunotherapy through protein language model.
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  Data: <searchLink fieldCode="AU" term="%22Eom+H%22">Eom H</searchLink>; Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+S%22">Park S</searchLink>; School of Biological Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cho+KS%22">Cho KS</searchLink>; Galux Inc, 1837 Nambusunhwan-ro, Gwanak-gu, Seoul 08738, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; School of Biological Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; School of Biological Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Galux Inc, 1837 Nambusunhwan-ro, Gwanak-gu, Seoul 08738, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Han+YH%22">Han YH</searchLink>; Galux Inc, 1837 Nambusunhwan-ro, Gwanak-gu, Seoul 08738, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.; School of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.; Arontier Co., 241 Gangnam-daero, Seocho-gu, Seoul 06735, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Seok+C%22">Seok C</searchLink>; Artificial Intelligence Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.; Institute of Molecular Biology and Genetics, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.; Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.; Galux Inc, 1837 Nambusunhwan-ro, Gwanak-gu, Seoul 08738, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+MS%22">Lee MS</searchLink>; Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.; Galux Inc, 1837 Nambusunhwan-ro, Gwanak-gu, Seoul 08738, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Song+WJ%22">Song WJ</searchLink>; Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Steinegger+M%22">Steinegger M</searchLink>; School of Biological Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.; Artificial Intelligence Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.; Institute of Molecular Biology and Genetics, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
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