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Design, Structure-Activity Relationships, and Computational Modeling Studies of a Series of α-Helix Biased, Ultra-Short Glucagon-like Peptide-1 Receptor Agonists.

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Title: Design, Structure-Activity Relationships, and Computational Modeling Studies of a Series of α-Helix Biased, Ultra-Short Glucagon-like Peptide-1 Receptor Agonists.
Authors: Sawyer JR; Resolute Bio, 48 Dunham Rd., Suite 5400, Beverly, MA 01915, USA.; Department of Chemistry and Biochemistry, The University of Arizona, 1306 E. University Blvd, Tucson, AZ 85721, USA.; Peptide Scientia, 8 Nathan Stone Lane, Southborough, MA 01772, USA., Audie JA; Eudoxia Life Sciences, 520 Squire Hill Rd., Cheshire, CT 06410, USA., Swanson J; Eudoxia Life Sciences, 520 Squire Hill Rd., Cheshire, CT 06410, USA., Diller D; Eudoxia Life Sciences, 520 Squire Hill Rd., Cheshire, CT 06410, USA., Santiago S; Resolute Bio, 48 Dunham Rd., Suite 5400, Beverly, MA 01915, USA., Gribkoff VK; Resolute Bio, 48 Dunham Rd., Suite 5400, Beverly, MA 01915, USA., Ackerman A; Resolute Bio, 48 Dunham Rd., Suite 5400, Beverly, MA 01915, USA., Hruby VJ; Department of Chemistry and Biochemistry, The University of Arizona, 1306 E. University Blvd, Tucson, AZ 85721, USA., Gobbo G; XtalPi US, XtalPi Inc., 245 Main Street, Cambridge, MA 02142, USA., Bellucci MA; XtalPi US, XtalPi Inc., 245 Main Street, Cambridge, MA 02142, USA., Glauser WA; XtalPi US, XtalPi Inc., 245 Main Street, Cambridge, MA 02142, USA., Pentelute BL; Resolute Bio, 48 Dunham Rd., Suite 5400, Beverly, MA 01915, USA., Sawyer TK; Resolute Bio, 48 Dunham Rd., Suite 5400, Beverly, MA 01915, USA.; Maestro Therapeutics, 8 Nathan Stone Lane, Southborough, MA 01772, USA.
Source: Molecules (Basel, Switzerland) [Molecules] 2024 Dec 24; Vol. 30 (1). Date of Electronic Publication: 2024 Dec 24.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design, Structure-Activity Relationships, and Computational Modeling Studies of a Series of α-Helix Biased, Ultra-Short Glucagon-like Peptide-1 Receptor Agonists.
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  Data: <searchLink fieldCode="AU" term="%22Sawyer+JR%22">Sawyer JR</searchLink>; Resolute Bio, 48 Dunham Rd., Suite 5400, Beverly, MA 01915, USA.; Department of Chemistry and Biochemistry, The University of Arizona, 1306 E. University Blvd, Tucson, AZ 85721, USA.; Peptide Scientia, 8 Nathan Stone Lane, Southborough, MA 01772, USA.<br /><searchLink fieldCode="AU" term="%22Audie+JA%22">Audie JA</searchLink>; Eudoxia Life Sciences, 520 Squire Hill Rd., Cheshire, CT 06410, USA.<br /><searchLink fieldCode="AU" term="%22Swanson+J%22">Swanson J</searchLink>; Eudoxia Life Sciences, 520 Squire Hill Rd., Cheshire, CT 06410, USA.<br /><searchLink fieldCode="AU" term="%22Diller+D%22">Diller D</searchLink>; Eudoxia Life Sciences, 520 Squire Hill Rd., Cheshire, CT 06410, USA.<br /><searchLink fieldCode="AU" term="%22Santiago+S%22">Santiago S</searchLink>; Resolute Bio, 48 Dunham Rd., Suite 5400, Beverly, MA 01915, USA.<br /><searchLink fieldCode="AU" term="%22Gribkoff+VK%22">Gribkoff VK</searchLink>; Resolute Bio, 48 Dunham Rd., Suite 5400, Beverly, MA 01915, USA.<br /><searchLink fieldCode="AU" term="%22Ackerman+A%22">Ackerman A</searchLink>; Resolute Bio, 48 Dunham Rd., Suite 5400, Beverly, MA 01915, USA.<br /><searchLink fieldCode="AU" term="%22Hruby+VJ%22">Hruby VJ</searchLink>; Department of Chemistry and Biochemistry, The University of Arizona, 1306 E. University Blvd, Tucson, AZ 85721, USA.<br /><searchLink fieldCode="AU" term="%22Gobbo+G%22">Gobbo G</searchLink>; XtalPi US, XtalPi Inc., 245 Main Street, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Bellucci+MA%22">Bellucci MA</searchLink>; XtalPi US, XtalPi Inc., 245 Main Street, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Glauser+WA%22">Glauser WA</searchLink>; XtalPi US, XtalPi Inc., 245 Main Street, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Pentelute+BL%22">Pentelute BL</searchLink>; Resolute Bio, 48 Dunham Rd., Suite 5400, Beverly, MA 01915, USA.<br /><searchLink fieldCode="AU" term="%22Sawyer+TK%22">Sawyer TK</searchLink>; Resolute Bio, 48 Dunham Rd., Suite 5400, Beverly, MA 01915, USA.; Maestro Therapeutics, 8 Nathan Stone Lane, Southborough, MA 01772, USA.
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  Data: <searchLink fieldCode="JN" term="%22100964009%22">Molecules (Basel, Switzerland)</searchLink> [Molecules] 2024 Dec 24; Vol. 30 (1). <i>Date of Electronic Publication: </i>2024 Dec 24.
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