CF2H-synthon enables asymmetric radical difluoroalkylation for synthesis of chiral difluoromethylated amines.
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| Title: | CF |
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| Authors: | Liu P; Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Department of Chemistry, University of Science and Technology of China, Hefei, China., He Y; Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Department of Chemistry, University of Science and Technology of China, Hefei, China., Jiang CH; Department of Chemistry, University of Science and Technology of China, Hefei, China., Ren WR; Department of Chemistry, University of Science and Technology of China, Hefei, China., Jin RX; Department of Chemistry, University of Science and Technology of China, Hefei, China., Zhang T; Department of Chemistry, University of Science and Technology of China, Hefei, China., Chen WX; Department of Chemistry, University of Science and Technology of China, Hefei, China., Nie X; Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. niexuan@ustc.edu.cn., Wang XS; Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. xswang77@ustc.edu.cn.; Department of Chemistry, University of Science and Technology of China, Hefei, China. xswang77@ustc.edu.cn. |
| Source: | Nature communications [Nat Commun] 2025 Jan 11; Vol. 16 (1), pp. 599. Date of Electronic Publication: 2025 Jan 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE; PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-55912-z |
