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CF2H-synthon enables asymmetric radical difluoroalkylation for synthesis of chiral difluoromethylated amines.

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Title: CF2H-synthon enables asymmetric radical difluoroalkylation for synthesis of chiral difluoromethylated amines.
Authors: Liu P; Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Department of Chemistry, University of Science and Technology of China, Hefei, China., He Y; Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Department of Chemistry, University of Science and Technology of China, Hefei, China., Jiang CH; Department of Chemistry, University of Science and Technology of China, Hefei, China., Ren WR; Department of Chemistry, University of Science and Technology of China, Hefei, China., Jin RX; Department of Chemistry, University of Science and Technology of China, Hefei, China., Zhang T; Department of Chemistry, University of Science and Technology of China, Hefei, China., Chen WX; Department of Chemistry, University of Science and Technology of China, Hefei, China., Nie X; Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. niexuan@ustc.edu.cn., Wang XS; Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. xswang77@ustc.edu.cn.; Department of Chemistry, University of Science and Technology of China, Hefei, China. xswang77@ustc.edu.cn.
Source: Nature communications [Nat Commun] 2025 Jan 11; Vol. 16 (1), pp. 599. Date of Electronic Publication: 2025 Jan 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE; PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: CF<subscript>2</subscript>H-synthon enables asymmetric radical difluoroalkylation for synthesis of chiral difluoromethylated amines.
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  Data: <searchLink fieldCode="AU" term="%22Liu+P%22">Liu P</searchLink>; Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Department of Chemistry, University of Science and Technology of China, Hefei, China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Department of Chemistry, University of Science and Technology of China, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Jiang+CH%22">Jiang CH</searchLink>; Department of Chemistry, University of Science and Technology of China, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Ren+WR%22">Ren WR</searchLink>; Department of Chemistry, University of Science and Technology of China, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Jin+RX%22">Jin RX</searchLink>; Department of Chemistry, University of Science and Technology of China, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; Department of Chemistry, University of Science and Technology of China, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Chen+WX%22">Chen WX</searchLink>; Department of Chemistry, University of Science and Technology of China, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Nie+X%22">Nie X</searchLink>; Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. niexuan@ustc.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+XS%22">Wang XS</searchLink>; Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. xswang77@ustc.edu.cn.; Department of Chemistry, University of Science and Technology of China, Hefei, China. xswang77@ustc.edu.cn.
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