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Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research.

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Title: Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research.
Authors: Merrill SM; Department of Psychology, University of Massachusetts Lowell, Lowell, MA, USA.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada., Konwar C; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada., Fatima F; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada., Dever K; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada., MacIsaac JL; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada., Letourneau N; Faculty of Nursing and Cumming School of Medicine, Departments of Pediatrics, Community Health Sciences and Psychiatry, University of Calgary, Calgary, AB, Canada.; Owerko Centre, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada., Giesbrecht GF; Owerko Centre, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada.; Department of Paediatrics and Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada., Dewey D; Faculty of Nursing and Cumming School of Medicine, Departments of Pediatrics, Community Health Sciences and Psychiatry, University of Calgary, Calgary, AB, Canada.; Department of Paediatrics and Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada., England-Mason G; Owerko Centre, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada.; Department of Paediatrics and Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Lewis CR; School of Life Sciences, Arizona State University, Tempe, AZ, USA., Wang D; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; National Heart and Lung Institute, Imperial College London, London, UK., Teh AL; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Meaney MJ; Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.; Program in Child and Brain Development, CIFAR, Toronto, ON, Canada., Gonzalez A; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada., Noll JG; Mount Hope Family Center and Department of Psychology, University of Rochester, Rochester, NY, USA., De Weerth C; Donders Institute for Brain, Cognition and Behaviour and Radbound University, Nijmegen, The Netherlands., Bush NR; Department of Psychiatry and Behavioral Sciences, Department of Pediatrics, University of California, Berkeley, CA, USA., O'Donnell KJ; Yale Child Study Center and Department of Obstetrics Gynaecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA., Stewart SE; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.; British Columbia Mental Health and Substance Use Services Research Institute and Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada., Kobor MS; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada. michael.kobor@ubc.ca.; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. michael.kobor@ubc.ca.; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada. michael.kobor@ubc.ca.; Program in Child and Brain Development, CIFAR, Toronto, ON, Canada. michael.kobor@ubc.ca.; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada. michael.kobor@ubc.ca.
Source: Nature communications [Nat Commun] 2025 Jan 12; Vol. 16 (1), pp. 609. Date of Electronic Publication: 2025 Jan 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-55909-8