Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease.

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Title: Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease.
Authors: Spencer PN; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Wang J; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Smith EP; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA., Spiga L; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Simmons AJ; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Kim T; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Kim W; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Brown ME; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Yang Y; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Kaur H; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Xu Y; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Kang SW; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Helou MD; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Lee MA; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Zheng L; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Arceneaux D; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Tasneem N; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Mueller KD; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA., Kuddar OS; Department of Molecular Genetics and Microbiology, Duke School of Medicine, Durham, NC 27710, USA., Harned MH; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Ro J; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Li J; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville TN, 37232, USA., Banerjee A; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA., Markham NO; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville TN, 37232, USA., Wilson KT; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville TN, 37232, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center; Nashville, TN, USA., Coburn LA; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville TN, 37232, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center; Nashville, TN, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Goettel JA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center; Nashville, TN, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Liu Q; Department of Biostatistics and Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville TN, 37232, USA., Kay Washington M; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville TN, 37232, USA., Valdivia RH; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA., Zhu W; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Lau KS; Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.; Center for Computational Systems Biology, Vanderbilt University, Nashville TN, 37232, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Surgery, Vanderbilt University Medical Center, Nashville TN, 37232, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jan 04. Date of Electronic Publication: 2025 Jan 04.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.01.04.630951