Lipid droplet targeting of the lipase coactivator ABHD5 and the fatty liver disease-causing variant PNPLA3 I148M is required to promote liver steatosis.

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Title: Lipid droplet targeting of the lipase coactivator ABHD5 and the fatty liver disease-causing variant PNPLA3 I148M is required to promote liver steatosis.
Authors: Teskey G; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA., Tiwari N; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA., Butcko AJ; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA; Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA., Kumar A; Department of Physics and Astronomy, Wayne State University, Detroit, Michigan, USA., Yadav A; Department of Physics and Astronomy, Wayne State University, Detroit, Michigan, USA., Huang YM; Department of Physics and Astronomy, Wayne State University, Detroit, Michigan, USA., Kelly CV; Department of Physics and Astronomy, Wayne State University, Detroit, Michigan, USA., Granneman JG; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA., Perfield JW; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis Indiana, USA., Mottillo EP; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA; Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA. Electronic address: emottil1@hfhs.org.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Feb; Vol. 301 (2), pp. 108186. Date of Electronic Publication: 2025 Jan 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1083-351X
DOI:10.1016/j.jbc.2025.108186