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Lipid droplet targeting of the lipase coactivator ABHD5 and the fatty liver disease-causing variant PNPLA3 I148M is required to promote liver steatosis.

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Title: Lipid droplet targeting of the lipase coactivator ABHD5 and the fatty liver disease-causing variant PNPLA3 I148M is required to promote liver steatosis.
Authors: Teskey G; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA., Tiwari N; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA., Butcko AJ; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA; Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA., Kumar A; Department of Physics and Astronomy, Wayne State University, Detroit, Michigan, USA., Yadav A; Department of Physics and Astronomy, Wayne State University, Detroit, Michigan, USA., Huang YM; Department of Physics and Astronomy, Wayne State University, Detroit, Michigan, USA., Kelly CV; Department of Physics and Astronomy, Wayne State University, Detroit, Michigan, USA., Granneman JG; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA., Perfield JW; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis Indiana, USA., Mottillo EP; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA; Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA. Electronic address: emottil1@hfhs.org.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Feb; Vol. 301 (2), pp. 108186. Date of Electronic Publication: 2025 Jan 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Lipid droplet targeting of the lipase coactivator ABHD5 and the fatty liver disease-causing variant PNPLA3 I148M is required to promote liver steatosis.
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  Data: <searchLink fieldCode="AU" term="%22Teskey+G%22">Teskey G</searchLink>; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Tiwari+N%22">Tiwari N</searchLink>; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Butcko+AJ%22">Butcko AJ</searchLink>; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA; Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+A%22">Kumar A</searchLink>; Department of Physics and Astronomy, Wayne State University, Detroit, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Yadav+A%22">Yadav A</searchLink>; Department of Physics and Astronomy, Wayne State University, Detroit, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Huang+YM%22">Huang YM</searchLink>; Department of Physics and Astronomy, Wayne State University, Detroit, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Kelly+CV%22">Kelly CV</searchLink>; Department of Physics and Astronomy, Wayne State University, Detroit, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Granneman+JG%22">Granneman JG</searchLink>; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Perfield+JW%22">Perfield JW</searchLink>; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Mottillo+EP%22">Mottillo EP</searchLink>; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA; Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA. Electronic address: emottil1@hfhs.org.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2025 Feb; Vol. 301 (2), pp. 108186. <i>Date of Electronic Publication: </i>2025 Jan 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jbc.2025.108186
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              Text: 2025 Feb
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