A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease.

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Title: A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease.
Authors: Young C; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St Vincent's Clinical School, UNSW Sydney, Sydney, NSW, Australia., Singh M; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St Vincent's Clinical School, UNSW Sydney, Sydney, NSW, Australia., Jackson KJL; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia., Field MA; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; Australian Institute of Tropical Health and Medicine and Centre for Tropical Bioinformatics and Molecular Biology, Smithfield, Cairns, QLD, Australia; Menzies School of Health Research, Darwin, NT, Australia., Peters TJ; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St Vincent's Clinical School, UNSW Sydney, Sydney, NSW, Australia., Angioletti-Uberti S; Department of Materials, Imperial College London, London, UK., Frenkel D; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Ravishankar S; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia., Gupta M; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia; The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia., Wang JJ; Department of Immunology, Flinders University and SA Pathology, Bedford Park, Adelaide, SA, Australia., Agapiou D; The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia., Faulks ML; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia., Al-Eryani G; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia., Luciani F; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia; The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia., Gordon TP; Department of Immunology, Flinders University and SA Pathology, Bedford Park, Adelaide, SA, Australia., Reed JH; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; Westmead Institute for Medical Research, Westmead, Sydney, NSW, Australia., Danta M; St Vincent's Clinical School, UNSW Sydney, Sydney, NSW, Australia., Carr A; Immunology and HIV Unit, St Vincent's Hospital, Sydney, NSW, Australia., Kelleher AD; The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia; Immunology and HIV Unit, St Vincent's Hospital, Sydney, NSW, Australia., Dore GJ; St Vincent's Clinical School, UNSW Sydney, Sydney, NSW, Australia; The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia., Matthews G; St Vincent's Clinical School, UNSW Sydney, Sydney, NSW, Australia; The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia., Brink R; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St Vincent's Clinical School, UNSW Sydney, Sydney, NSW, Australia., Bull RA; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia; The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia., Suan D; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St Vincent's Clinical School, UNSW Sydney, Sydney, NSW, Australia. Electronic address: d.suan@garvan.org.au., Goodnow CC; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St Vincent's Clinical School, UNSW Sydney, Sydney, NSW, Australia. Electronic address: c.goodnow@garvan.org.au.
Source: Immunity [Immunity] 2025 Feb 11; Vol. 58 (2), pp. 412-430.e10. Date of Electronic Publication: 2025 Jan 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4180
DOI:10.1016/j.immuni.2024.12.011