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Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease.

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Title: Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease.
Authors: Chau LF; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Lillico S; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Opriessnig T; Moredun Research Institute, Edinburgh, UK., Blake R; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Tardy L; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Lee CH; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Maxwell S; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Warren C; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Thornton E; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Mclaughlin CL; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., McLachlan G; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Tait-Burkard C; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Fletcher S; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Anderson S; Moredun Research Institute, Edinburgh, UK., Brown S; Moredun Research Institute, Edinburgh, UK., Gibbard L; Moredun Research Institute, Edinburgh, UK., Tzelos T; Moredun Research Institute, Edinburgh, UK., MacMillan-Christensen D; Moredun Research Institute, Edinburgh, UK., Baillie JK; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.; Baillie Gifford Pandemic Science Hub, University of Edinburgh, Edinburgh, UK., Dorward DA; Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.; Department of Pathology, Royal Infirmary, Edinburgh, UK., Griffiths DJ; Moredun Research Institute, Edinburgh, UK. David.Griffiths@moredun.ac.uk., Grey F; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK. fgrey@exseed.ed.ac.uk.
Source: Nature communications [Nat Commun] 2025 Jan 17; Vol. 16 (1), pp. 766. Date of Electronic Publication: 2025 Jan 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-024-54615-1