Zinc Combined with Metformin Corrects Zinc Homeostasis and Improves Steroid Synthesis and Semen Quality in Male Type 2 Diabetic Mice by Activating PI3K/AKT/mTOR Pathway.

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Title: Zinc Combined with Metformin Corrects Zinc Homeostasis and Improves Steroid Synthesis and Semen Quality in Male Type 2 Diabetic Mice by Activating PI3K/AKT/mTOR Pathway.
Authors: Li H; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China., Zhang M; Department of Blood Transfusion, Hebei Children's Hospital, Shijiazhuang 050031, Hebei, China., Ma J; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China., Li W; Department of Imaging, Hebei Chest Hospital, Shijiazhuang 050041, Hebei, China., Liu X; Graduate School of Hebei Medical University, Shijiazhuang 050017, Hebei, China., Li Y; Department of College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050024, Hebei, China., Ma J; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China., Yang D; Graduate School, North China University of Science and Technology, Hebei, 063210, China., Tie Y; Graduate School, North China University of Science and Technology, Hebei, 063210, China. tyq1995@126.com.; Department of Laboratory, Hebei General Hospital, Shijiazhuang 050051, Hebei, China. tyq1995@126.com., Bai H; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China. 907395452@qq.com., Wang S; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China. wshsong@126.com.; Graduate School of Hebei Medical University, Shijiazhuang 050017, Hebei, China. wshsong@126.com.; Department of College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050024, Hebei, China. wshsong@126.com.
Source: Biological trace element research [Biol Trace Elem Res] 2025 Sep; Vol. 203 (9), pp. 4659-4670. Date of Electronic Publication: 2025 Jan 18.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1559-0720
DOI:10.1007/s12011-025-04518-z