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Zinc Combined with Metformin Corrects Zinc Homeostasis and Improves Steroid Synthesis and Semen Quality in Male Type 2 Diabetic Mice by Activating PI3K/AKT/mTOR Pathway.

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Title: Zinc Combined with Metformin Corrects Zinc Homeostasis and Improves Steroid Synthesis and Semen Quality in Male Type 2 Diabetic Mice by Activating PI3K/AKT/mTOR Pathway.
Authors: Li H; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China., Zhang M; Department of Blood Transfusion, Hebei Children's Hospital, Shijiazhuang 050031, Hebei, China., Ma J; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China., Li W; Department of Imaging, Hebei Chest Hospital, Shijiazhuang 050041, Hebei, China., Liu X; Graduate School of Hebei Medical University, Shijiazhuang 050017, Hebei, China., Li Y; Department of College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050024, Hebei, China., Ma J; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China., Yang D; Graduate School, North China University of Science and Technology, Hebei, 063210, China., Tie Y; Graduate School, North China University of Science and Technology, Hebei, 063210, China. tyq1995@126.com.; Department of Laboratory, Hebei General Hospital, Shijiazhuang 050051, Hebei, China. tyq1995@126.com., Bai H; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China. 907395452@qq.com., Wang S; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China. wshsong@126.com.; Graduate School of Hebei Medical University, Shijiazhuang 050017, Hebei, China. wshsong@126.com.; Department of College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050024, Hebei, China. wshsong@126.com.
Source: Biological trace element research [Biol Trace Elem Res] 2025 Sep; Vol. 203 (9), pp. 4659-4670. Date of Electronic Publication: 2025 Jan 18.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Zinc Combined with Metformin Corrects Zinc Homeostasis and Improves Steroid Synthesis and Semen Quality in Male Type 2 Diabetic Mice by Activating PI3K/AKT/mTOR Pathway.
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  Data: <searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Department of Blood Transfusion, Hebei Children's Hospital, Shijiazhuang 050031, Hebei, China.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Department of Imaging, Hebei Chest Hospital, Shijiazhuang 050041, Hebei, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Graduate School of Hebei Medical University, Shijiazhuang 050017, Hebei, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050024, Hebei, China.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China.<br /><searchLink fieldCode="AU" term="%22Yang+D%22">Yang D</searchLink>; Graduate School, North China University of Science and Technology, Hebei, 063210, China.<br /><searchLink fieldCode="AU" term="%22Tie+Y%22">Tie Y</searchLink>; Graduate School, North China University of Science and Technology, Hebei, 063210, China. tyq1995@126.com.; Department of Laboratory, Hebei General Hospital, Shijiazhuang 050051, Hebei, China. tyq1995@126.com.<br /><searchLink fieldCode="AU" term="%22Bai+H%22">Bai H</searchLink>; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China. 907395452@qq.com.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China. wshsong@126.com.; Graduate School of Hebei Medical University, Shijiazhuang 050017, Hebei, China. wshsong@126.com.; Department of College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050024, Hebei, China. wshsong@126.com.
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  Data: <searchLink fieldCode="JN" term="%227911509%22">Biological trace element research</searchLink> [Biol Trace Elem Res] 2025 Sep; Vol. 203 (9), pp. 4659-4670. <i>Date of Electronic Publication: </i>2025 Jan 18.
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              Text: 2025 Sep
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