Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines.

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Title: Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines.
Authors: Sherry L; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Bahar MW; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Oxford, UK., Porta C; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Oxford, UK.; The Pirbright Institute, Surrey, UK., Fox H; Division of Vaccines, Medicines & Healthcare products Regulatory Agency (MHRA), Herts, UK., Grehan K; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Nasta V; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Oxford, UK.; Magnetic Resonance Center CERM, University of Florence, Sesto Fiorentino, Florence, Italy., Duyvesteyn HME; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Oxford, UK., De Colibus L; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Oxford, UK., Marsian J; John Innes Centre, Norwich Research Park, Norwich, UK., Murdoch I; John Innes Centre, Norwich Research Park, Norwich, UK., Ponndorf D; John Innes Centre, Norwich Research Park, Norwich, UK., Kim SR; John Innes Centre, Norwich Research Park, Norwich, UK., Shah S; John Innes Centre, Norwich Research Park, Norwich, UK., Carlyle S; Division of Vaccines, Medicines & Healthcare products Regulatory Agency (MHRA), Herts, UK., Swanson JJ; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Matthews S; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Nicol C; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Lomonossoff GP; John Innes Centre, Norwich Research Park, Norwich, UK. george.lomonossoff@jic.ac.uk., Macadam AJ; Division of Vaccines, Medicines & Healthcare products Regulatory Agency (MHRA), Herts, UK. andrew.macadam@mhra.gov.uk., Fry EE; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Oxford, UK. elizabeth.fry@strubi.ox.ac.uk., Stuart DI; Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Oxford, UK. dave.stuart@strubi.ox.ac.uk.; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK. dave.stuart@strubi.ox.ac.uk., Stonehouse NJ; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK. n.j.stonehouse@leeds.ac.uk., Rowlands DJ; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK. d.j.rowlands@leeds.ac.uk.
Source: Nature communications [Nat Commun] 2025 Jan 18; Vol. 16 (1), pp. 831. Date of Electronic Publication: 2025 Jan 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-56118-z