Relaxin mimetic in pulmonary hypertension associated with left heart disease: Design and rationale of Re-PHIRE.

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Title: Relaxin mimetic in pulmonary hypertension associated with left heart disease: Design and rationale of Re-PHIRE.
Authors: Ufnal M; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Warsaw, Poland., Connolly K; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Millegard M; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Surkova E; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Guazzi M; University of Milan School of Medicine, San Paolo University Hospital, Milan, Italy., Bonderman D; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Ezekowitz J; Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada., Gustafsson F; The Heart Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Ciurzyński M; Department of Internal Medicine and Cardiology with the Centre for Management of Venous Thromboembolic Disease, Medical University of Warsaw, Warsaw, Poland., Vilella RL; Heart Failure and Transplantation Unit, La Fe University and Polytechnic Hospital, Valencia, Spain., Ahmad T; Heart Failure Program, Yale School of Medicine, New Haven, Connecticut, USA., Gardner R; Scottish National Advanced Heart Failure Service, Golden Jubilee National Hospital, Clydebank, UK., Jansa P; 2nd Department of Medicine, Charles University and General University Hospital, Prague, Czechia., van Wijk S; Department of Cardiology, Zuyderland Medical Center, Heerlen, The Netherlands., Kinugawa K; Second Department of Internal Medicine, University of Toyama, Toyama, Japan., Björklund E; Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden., Jing ZC; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China., Rosenkranz S; Department of Cardiology, Pulmonology, and Intensive Care Medicine, Center for Molecular Medicine Cologne (CMMC), Cologne Cardiovascular Research Center (CCRC), Medical Faculty, University of Cologne, Cologne, Germany.
Source: ESC heart failure [ESC Heart Fail] 2025 Jun; Vol. 12 (3), pp. 1956-1964. Date of Electronic Publication: 2025 Jan 20.
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: John Wiley & Sons Ltd on behalf of the European Society of Cardiology Country of Publication: England NLM ID: 101669191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2055-5822 (Electronic) Linking ISSN: 20555822 NLM ISO Abbreviation: ESC Heart Fail Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2055-5822
DOI:10.1002/ehf2.15203