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Two-layered immune escape in AML is overcome by Fcγ receptor activation and inhibition of PGE2 signaling in NK cells.

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Title: Two-layered immune escape in AML is overcome by Fcγ receptor activation and inhibition of PGE2 signaling in NK cells.
Authors: Rothfuß C; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany., Baumann T; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany., Donakonda S; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany., Brauchle B; Gene Center, Laboratory for Translational Cancer Immunology, Ludwig-Maximilians-Universität München, Munich, Germany., Marcinek A; Gene Center, Laboratory for Translational Cancer Immunology, Ludwig-Maximilians-Universität München, Munich, Germany., Urban C; Institute of Virology, School of Medicine and Health, Technical University of Munich, Munich, Germany., Mergner J; Bavarian Center for Biomolecular Mass Spectrometry at Munich Institute of Robotics and Machine Intelligence, Technical University of Munich, Munich, Germany., Pedde AM; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany., Hirschberger A; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany., Krupka C; Gene Center, Laboratory for Translational Cancer Immunology, Ludwig-Maximilians-Universität München, Munich, Germany., Neumann AS; Gene Center, Laboratory for Translational Cancer Immunology, Ludwig-Maximilians-Universität München, Munich, Germany., Hänel G; Gene Center, Laboratory for Translational Cancer Immunology, Ludwig-Maximilians-Universität München, Munich, Germany., Merten C; Institut of Molecular and Clinical Immunology, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany., Öllinger R; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, Technical University of Munich, Munich, Germany., Hecker JS; Department of Medicine III, Technical University of Munich, School of Medicine and Health, Munich, Germany., Bauer T; Institute of Virology, School of Medicine and Health, Technical University of Munich, Munich, Germany., Schmid C; Food Chemistry and Molecular Sensory Science, Technical University of Munich, Munich, Germany., Götze KS; Department of Medicine III, Technical University of Munich, School of Medicine and Health, Munich, Germany., Altomonte J; Department of Internal Medicine II, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Bücklein V; Gene Center, Laboratory for Translational Cancer Immunology, Ludwig-Maximilians-Universität München, Munich, Germany., Jacobs R; Department of Rheumatology and Clinical Immunology, Hannover Medical School, Hannover, Germany., Rad R; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, Technical University of Munich, Munich, Germany., Dawid C; Food Chemistry and Molecular Sensory Science, Technical University of Munich, Munich, Germany., Simeoni L; Institut of Molecular and Clinical Immunology, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany., Schraven B; Institut of Molecular and Clinical Immunology, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany., Pichlmair A; Institute of Virology, School of Medicine and Health, Technical University of Munich, Munich, Germany., Subklewe M; Gene Center, Laboratory for Translational Cancer Immunology, Ludwig-Maximilians-Universität München, Munich, Germany., Knolle PA; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Institute of Molecular Immunology, School of Life Science, Technical University of Munich, Munich, Germany., Böttcher JP; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Department of Experimental Immunology, Institute of Immunology, University of Tübingen, Tübingen, Germany., Höchst B; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Source: Blood [Blood] 2025 Mar 27; Vol. 145 (13), pp. 1395-1406.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
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  Data: Two-layered immune escape in AML is overcome by Fcγ receptor activation and inhibition of PGE2 signaling in NK cells.
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  Data: <searchLink fieldCode="AU" term="%22Rothfuß+C%22">Rothfuß C</searchLink>; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Baumann+T%22">Baumann T</searchLink>; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Donakonda+S%22">Donakonda S</searchLink>; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Brauchle+B%22">Brauchle B</searchLink>; Gene Center, Laboratory for Translational Cancer Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Marcinek+A%22">Marcinek A</searchLink>; Gene Center, Laboratory for Translational Cancer Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Urban+C%22">Urban C</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mergner+J%22">Mergner J</searchLink>; Bavarian Center for Biomolecular Mass Spectrometry at Munich Institute of Robotics and Machine Intelligence, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Pedde+AM%22">Pedde AM</searchLink>; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hirschberger+A%22">Hirschberger A</searchLink>; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Krupka+C%22">Krupka C</searchLink>; Gene Center, Laboratory for Translational Cancer Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Neumann+AS%22">Neumann AS</searchLink>; Gene Center, Laboratory for Translational Cancer Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hänel+G%22">Hänel G</searchLink>; Gene Center, Laboratory for Translational Cancer Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Merten+C%22">Merten C</searchLink>; Institut of Molecular and Clinical Immunology, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Öllinger+R%22">Öllinger R</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hecker+JS%22">Hecker JS</searchLink>; Department of Medicine III, Technical University of Munich, School of Medicine and Health, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bauer+T%22">Bauer T</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schmid+C%22">Schmid C</searchLink>; Food Chemistry and Molecular Sensory Science, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Götze+KS%22">Götze KS</searchLink>; Department of Medicine III, Technical University of Munich, School of Medicine and Health, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Altomonte+J%22">Altomonte J</searchLink>; Department of Internal Medicine II, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bücklein+V%22">Bücklein V</searchLink>; Gene Center, Laboratory for Translational Cancer Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jacobs+R%22">Jacobs R</searchLink>; Department of Rheumatology and Clinical Immunology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Rad+R%22">Rad R</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Dawid+C%22">Dawid C</searchLink>; Food Chemistry and Molecular Sensory Science, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Simeoni+L%22">Simeoni L</searchLink>; Institut of Molecular and Clinical Immunology, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schraven+B%22">Schraven B</searchLink>; Institut of Molecular and Clinical Immunology, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Pichlmair+A%22">Pichlmair A</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Subklewe+M%22">Subklewe M</searchLink>; Gene Center, Laboratory for Translational Cancer Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Knolle+PA%22">Knolle PA</searchLink>; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Institute of Molecular Immunology, School of Life Science, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Böttcher+JP%22">Böttcher JP</searchLink>; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Department of Experimental Immunology, Institute of Immunology, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Höchst+B%22">Höchst B</searchLink>; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany.
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