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Oral vs Intravenous Antibiotics for Fracture-Related Infections: The POvIV Randomized Clinical Trial.

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Title: Oral vs Intravenous Antibiotics for Fracture-Related Infections: The POvIV Randomized Clinical Trial.
Authors: Obremskey WT; Vanderbilt University Medical Center, Nashville, Tennessee., O'Toole RV; R Adams Cowley Shock Trauma Center at the University of Maryland School of Medicine, Baltimore., Morshed S; The University of California, San Francisco., Tornetta P 3rd; Boston Medical Center, Boston, Massachusetts., Murray CK; Brooke Army Medical Center, Fort Sam Houston, Texas., Jones CB; Center for Orthopedic Research and Education, Phoenix, Arizona.; Now with Dignity Health, Creighton Medical Phoenix, Phoenix, Arizona., Scharfstein DO; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Taylor TJ; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Carlini AR; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., DeSanto JM; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Castillo RC; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Bosse MJ; Atrium Health Carolinas Medical Center, Charlotte, North Carolina., Karunakar MA; Atrium Health Carolinas Medical Center, Charlotte, North Carolina., Seymour RB; Atrium Health Carolinas Medical Center, Charlotte, North Carolina., Sims SH; Atrium Health Carolinas Medical Center, Charlotte, North Carolina., Weinrib DA; Atrium Health Carolinas Medical Center, Charlotte, North Carolina., Churchill C; Atrium Health Carolinas Medical Center, Charlotte, North Carolina., Carroll EA; Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina., Pilson HT; Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina., Goodman JB; Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina., Holden MB; Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina., Miller AN; Barnes-Jewish Hospital at Washington University in St Louis, St Louis, Missouri., Sietsema DL; Center for Orthopedic Research and Education, Phoenix, Arizona., Stahel PF; Denver Health and Hospital Authority, Denver, Colorado., Mir H; Florida Orthopaedic Institute, Tampa., Schmidt AH; Hennepin Healthcare, Minneapolis, Minnesota., Westberg JR; Hennepin Healthcare, Minneapolis, Minnesota., Mullis B; Eskenazi Health, Indiana University, Indianapolis, Indiana., Shively KD; Eskenazi Health, Indiana University, Indianapolis, Indiana., Hymes RA; Inova Fairfax Medical Campus, Annandale, Virginia., Konda SR; Jamaica Hospital Medical Center, Queens, New York., Vallier HA; MetroHealth Medical Center, Cleveland, Ohio., Breslin MA; MetroHealth Medical Center, Cleveland, Ohio., Smith CS; Naval Medical Center Portsmouth, Portsmouth, Virginia., Crickard CV; Naval Medical Center Portsmouth, Portsmouth, Virginia., Egol KA; New York University, New York., Reid JS; Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania., Baker M; R Adams Cowley Shock Trauma Center at the University of Maryland School of Medicine, Baltimore., Eglseder WA; R Adams Cowley Shock Trauma Center at the University of Maryland School of Medicine, Baltimore., LeBrun C; R Adams Cowley Shock Trauma Center at the University of Maryland School of Medicine, Baltimore., Manson T; R Adams Cowley Shock Trauma Center at the University of Maryland School of Medicine, Baltimore., Mascarenhas DC; R Adams Cowley Shock Trauma Center at the University of Maryland School of Medicine, Baltimore., Nascone J; R Adams Cowley Shock Trauma Center at the University of Maryland School of Medicine, Baltimore., Pollak AN; R Adams Cowley Shock Trauma Center at the University of Maryland School of Medicine, Baltimore., Schloss MG; R Adams Cowley Shock Trauma Center at the University of Maryland School of Medicine, Baltimore., Sciadini MF; R Adams Cowley Shock Trauma Center at the University of Maryland School of Medicine, Baltimore., Degani Y; R Adams Cowley Shock Trauma Center at the University of Maryland School of Medicine, Baltimore., Miclau T; The University of California, San Francisco., Weiss DB; University of Virginia Health, Charlottesville., Yarboro SR; University of Virginia Health, Charlottesville., McVey ED; University of Virginia Health, Charlottesville., Firoozabadi R; University of Washington Medicine Harborview Medical Center, Seattle., Agel J; University of Washington Medicine Harborview Medical Center, Seattle., Whiting PS; University of Wisconsin, Madison., Haleem A; University of Wisconsin, Madison., Domes C; University of Wisconsin, Madison., Lang GJ; University of Wisconsin, Madison., Kuhn GR; University of Wisconsin, Madison., Archer KR; Vanderbilt University Medical Center, Nashville, Tennessee., Talbot T; Vanderbilt University Medical Center, Nashville, Tennessee., Burgos EJ; Vanderbilt University Medical Center, Nashville, Tennessee., Gajari V; Vanderbilt University Medical Center, Nashville, Tennessee., Herrera LN; Vanderbilt University Medical Center, Nashville, Tennessee., Rodriguez-Buitrago A; Vanderbilt University Medical Center, Nashville, Tennessee., Tummuru RR; Vanderbilt University Medical Center, Nashville, Tennessee., Abraham CM; Vanderbilt University Medical Center, Nashville, Tennessee.; Now with Good Shepherd Rehabilitation Network, Center Valley, Pennsylvania., Trochez KM; Vanderbilt University Medical Center, Nashville, Tennessee.
Corporate Authors: Major Extremity Trauma Research Consortium (METRC)
Source: JAMA surgery [JAMA Surg] 2025 Mar 01; Vol. 160 (3), pp. 276-284.
Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589553 Publication Model: Print Cited Medium: Internet ISSN: 2168-6262 (Electronic) Linking ISSN: 21686254 NLM ISO Abbreviation: JAMA Surg Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2168-6262
DOI:10.1001/jamasurg.2024.6439