Aging and inflammation limit the induction of SARS-CoV-2-specific CD8+ T cell responses in severe COVID-19.

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Title: Aging and inflammation limit the induction of SARS-CoV-2-specific CD8+ T cell responses in severe COVID-19.
Authors: Autaa G; University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France., Papagno L; University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France., Nogimori T; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan., Boizard-Moracchini A; CHU Bordeaux, Laboratory of Immunology and Immunogenetics, 33000 Bordeaux, France., Korenkov D; University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France., Roy M; CHU Bordeaux, Laboratory of Immunology and Immunogenetics, 33000 Bordeaux, France., Suzuki K; The Research Foundation for Microbial Diseases of Osaka University (BIKEN), Osaka, Japan., Masuta Y; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan., White E; University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France., Llewellyn-Lacey S; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom., Yoshioka Y; The Research Foundation for Microbial Diseases of Osaka University (BIKEN), Osaka, Japan.; Vaccine Creation Group, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases.; Laboratory of Nano-Design for Innovative Drug Development, Graduate School of Pharmaceutical Sciences, and.; Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan., Nicoli F; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Price DA; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.; Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom., Dechanet-Merville J; University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France., Yamamoto T; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan., Pellegrin I; University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France.; CHU Bordeaux, Laboratory of Immunology and Immunogenetics, 33000 Bordeaux, France., Appay V; University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France.; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Source: JCI insight [JCI Insight] 2025 Jan 23; Vol. 10 (4). Date of Electronic Publication: 2025 Jan 23.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Aging and inflammation limit the induction of SARS-CoV-2-specific CD8+ T cell responses in severe COVID-19.
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  Data: <searchLink fieldCode="AU" term="%22Autaa+G%22">Autaa G</searchLink>; University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Papagno+L%22">Papagno L</searchLink>; University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Nogimori+T%22">Nogimori T</searchLink>; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Boizard-Moracchini+A%22">Boizard-Moracchini A</searchLink>; CHU Bordeaux, Laboratory of Immunology and Immunogenetics, 33000 Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Korenkov+D%22">Korenkov D</searchLink>; University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Roy+M%22">Roy M</searchLink>; CHU Bordeaux, Laboratory of Immunology and Immunogenetics, 33000 Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Suzuki+K%22">Suzuki K</searchLink>; The Research Foundation for Microbial Diseases of Osaka University (BIKEN), Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Masuta+Y%22">Masuta Y</searchLink>; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22White+E%22">White E</searchLink>; University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Llewellyn-Lacey+S%22">Llewellyn-Lacey S</searchLink>; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Yoshioka+Y%22">Yoshioka Y</searchLink>; The Research Foundation for Microbial Diseases of Osaka University (BIKEN), Osaka, Japan.; Vaccine Creation Group, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases.; Laboratory of Nano-Design for Innovative Drug Development, Graduate School of Pharmaceutical Sciences, and.; Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nicoli+F%22">Nicoli F</searchLink>; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Price+DA%22">Price DA</searchLink>; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.; Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dechanet-Merville+J%22">Dechanet-Merville J</searchLink>; University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Yamamoto+T%22">Yamamoto T</searchLink>; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Pellegrin+I%22">Pellegrin I</searchLink>; University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France.; CHU Bordeaux, Laboratory of Immunology and Immunogenetics, 33000 Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Appay+V%22">Appay V</searchLink>; University of Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France.; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2025 Jan 23; Vol. 10 (4). <i>Date of Electronic Publication: </i>2025 Jan 23.
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