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Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques.

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Title: Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques.
Authors: Edwards CT; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Karunakaran KA; Department of Pathology, Microbiology & Immunology, Vanderbilt University, Nashville, Tennessee, United States of America., Garcia E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Mayo Clinic Medical Scientist Training Program, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, United States of America., Beutler N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America., Gagne M; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Golden N; Tulane National Primate Research Center, Covington, Los Angeles, United States of America., Aoued H; Emory National Primate Research Center Genomics Core, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Pellegrini KL; Emory National Primate Research Center Genomics Core, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Burnett MR; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Honeycutt CC; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Lapp SA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Ton T; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Lin MC; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Metz A; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Bombin A; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America., Goff K; Tulane National Primate Research Center, Covington, Los Angeles, United States of America., Scheuermann SE; Tulane National Primate Research Center, Covington, Los Angeles, United States of America., Wilkes A; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Wood JS; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Ehnert S; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Weissman S; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Curran EH; Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Roy M; Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Dessasau E; Division of Histology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Paiardini M; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Emory Vaccine Center, Emory National Primate Research Center, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America., Upadhyay AA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Moore IN; Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America., Maness NJ; Tulane National Primate Research Center, Covington, Los Angeles, United States of America., Douek DC; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Piantadosi A; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Emory Vaccine Center, Emory National Primate Research Center, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America., Andrabi R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America., Rogers TR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, California, United States of America., Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, United States of America., Bosinger SE; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Emory Vaccine Center, Emory National Primate Research Center, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Source: PLoS pathogens [PLoS Pathog] 2025 Jan 23; Vol. 21 (1), pp. e1012456. Date of Electronic Publication: 2025 Jan 23 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1553-7374
DOI:10.1371/journal.ppat.1012456