KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid.

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Title: KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid.
Authors: McLean TC; Department of Molecular Microbiology, John Innes Centre, Norwich, UK. thomas.mcLean@jic.ac.uk., Balaguer-Pérez F; Department of Macromolecular Structures, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain., Chandanani J; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA., Thomas CM; School of Biosciences, University of Birmingham, Birmingham, UK., Aicart-Ramos C; Department of Macromolecular Structures, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain., Burick S; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA., Olinares PDB; Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY, USA., Gobbato G; Department of Molecular Microbiology, John Innes Centre, Norwich, UK., Mundy JEA; Department of Biochemistry and Metabolism, John Innes Centre, Norwich, UK., Chait BT; Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY, USA., Lawson DM; Department of Biochemistry and Metabolism, John Innes Centre, Norwich, UK., Darst SA; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA. darst@rockefeller.edu., Campbell EA; Laboratory of Molecular Pathogenesis, The Rockefeller University, New York, NY, USA. campbee@rockefeller.edu., Moreno-Herrero F; Department of Macromolecular Structures, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain. fernando.moreno@cnb.csic.es., Le TBK; Department of Molecular Microbiology, John Innes Centre, Norwich, UK. tung.le@jic.ac.uk.
Source: Nature microbiology [Nat Microbiol] 2025 Feb; Vol. 10 (2), pp. 448-467. Date of Electronic Publication: 2025 Jan 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2058-5276
DOI:10.1038/s41564-024-01915-3