Protective effect of valsartan alone and in combination with neprilysin inhibitor (valsartan + sacubitril) against hepatic ischemia-reperfusion injury: targeting angiotensin II receptor-neprilysin and modulating SMAD-4/NF-κβ/JNK pathways in rats.
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| Title: | Protective effect of valsartan alone and in combination with neprilysin inhibitor (valsartan + sacubitril) against hepatic ischemia-reperfusion injury: targeting angiotensin II receptor-neprilysin and modulating SMAD-4/NF-κβ/JNK pathways in rats. |
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| Authors: | Elsayed Abouzed DE; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Sohag University, Sohag, 82524, Egypt. deiaaabozed@pharm.sohag.edu.eg., Bafail DA; Department of Clinical Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Refaie SM; Department of Biomedical Science, Faculty of Medicine, King Faisal University, 36375, Hofuf, Saudi Arabia., Aboelez MO; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, 82524, Egypt., Elsayed AA; Clinical Pharmacy, Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag, 82524, Egypt., Mallasiy LO; Muhayil Asir, Applied College, King Khalid University, 61913, Abha, Saudi Arabia., Bayoumy NMK; Department of Physiology, College of Medicine, King Saud University, 12271, Riyadh, Saudi Arabia., Hagar H; Department of Physiology, College of Medicine, King Saud University, 12271, Riyadh, Saudi Arabia.; Department of Pharmacology, College of Pharmacy, Zagazig University, Zagazig, 44511, Egypt. |
| Source: | Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Jul; Vol. 398 (7), pp. 8797-8811. Date of Electronic Publication: 2025 Jan 27. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1432-1912 |
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| DOI: | 10.1007/s00210-025-03820-w |
