Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing.

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Title: Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing.
Authors: Scott TM; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Arnold LM; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Powers JA; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., McCann DA; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Rowe AB; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Christensen DE; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Pereira MJ; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Zhou W; Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China., Torrez RM; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Iwasa JH; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Kranzusch PJ; Department of Microbiology, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America., Sundquist WI; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Johnson JS; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
Source: PLoS pathogens [PLoS Pathog] 2025 Jan 28; Vol. 21 (1), pp. e1012206. Date of Electronic Publication: 2025 Jan 28 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1553-7374
DOI:10.1371/journal.ppat.1012206