The PROPHECI trial: a phase II, double-blind, placebo-controlled, randomized clinical trial for the treatment of pseudoxanthoma elasticum with oral pyrophosphate.

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Title: The PROPHECI trial: a phase II, double-blind, placebo-controlled, randomized clinical trial for the treatment of pseudoxanthoma elasticum with oral pyrophosphate.
Authors: Clotaire L; Université Côte d'Azur, CNRS, LP2M, Nice, France.; Research and Development Department, Laboratoires ProNutri, Carros, France., Rubera I; Université Côte d'Azur, CNRS, LP2M, Nice, France., Duranton C; Université Côte d'Azur, CNRS, LP2M, Nice, France., Gal J; Statistics Department, Centre Antoine Lacassagne, Nice, France., Chamorey E; Statistics Department, Centre Antoine Lacassagne, Nice, France., Humeau H; Ophthalmology Department, Centre Hospitalo-Universitaire d'Angers, Angers, France., Yamani S; Drug Safety Department, Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France., Chiaverini C; Dermatology Department, Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France., Willoteaux S; Radiology Department, Centre Hospitalo-Universitaire d'Angers, Angers, France., Padovani B; Radiology Department, Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France., Mourozeau L; Ophthalmology Department, Centre Hospitalo-Universitaire d'Angers, Angers, France., Mainguy A; Ophthalmology Department, Centre Hospitalo-Universitaire d'Angers, Angers, France., Baillif S; Ophthalmology Department, Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France., Martin L; Centre Hospitalo-Universitaire d'Angers, PXE National Reference Center, Angers, France.; Dermatology Department, Centre Hospitalo-Universitaire d'Angers, Angers, France., Leftheriotis G; Université Côte d'Azur, CNRS, LP2M, Nice, France. leftheriotis.g@chu-nice.fr.; National Center for Rare Arterial Diseases, Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France. leftheriotis.g@chu-nice.fr.
Source: Trials [Trials] 2025 Jan 29; Vol. 26 (1), pp. 30. Date of Electronic Publication: 2025 Jan 29.
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The PROPHECI trial: a phase II, double-blind, placebo-controlled, randomized clinical trial for the treatment of pseudoxanthoma elasticum with oral pyrophosphate.
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  Data: <searchLink fieldCode="AU" term="%22Clotaire+L%22">Clotaire L</searchLink>; Université Côte d'Azur, CNRS, LP2M, Nice, France.; Research and Development Department, Laboratoires ProNutri, Carros, France.<br /><searchLink fieldCode="AU" term="%22Rubera+I%22">Rubera I</searchLink>; Université Côte d'Azur, CNRS, LP2M, Nice, France.<br /><searchLink fieldCode="AU" term="%22Duranton+C%22">Duranton C</searchLink>; Université Côte d'Azur, CNRS, LP2M, Nice, France.<br /><searchLink fieldCode="AU" term="%22Gal+J%22">Gal J</searchLink>; Statistics Department, Centre Antoine Lacassagne, Nice, France.<br /><searchLink fieldCode="AU" term="%22Chamorey+E%22">Chamorey E</searchLink>; Statistics Department, Centre Antoine Lacassagne, Nice, France.<br /><searchLink fieldCode="AU" term="%22Humeau+H%22">Humeau H</searchLink>; Ophthalmology Department, Centre Hospitalo-Universitaire d'Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Yamani+S%22">Yamani S</searchLink>; Drug Safety Department, Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France.<br /><searchLink fieldCode="AU" term="%22Chiaverini+C%22">Chiaverini C</searchLink>; Dermatology Department, Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France.<br /><searchLink fieldCode="AU" term="%22Willoteaux+S%22">Willoteaux S</searchLink>; Radiology Department, Centre Hospitalo-Universitaire d'Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Padovani+B%22">Padovani B</searchLink>; Radiology Department, Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France.<br /><searchLink fieldCode="AU" term="%22Mourozeau+L%22">Mourozeau L</searchLink>; Ophthalmology Department, Centre Hospitalo-Universitaire d'Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Mainguy+A%22">Mainguy A</searchLink>; Ophthalmology Department, Centre Hospitalo-Universitaire d'Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Baillif+S%22">Baillif S</searchLink>; Ophthalmology Department, Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France.<br /><searchLink fieldCode="AU" term="%22Martin+L%22">Martin L</searchLink>; Centre Hospitalo-Universitaire d'Angers, PXE National Reference Center, Angers, France.; Dermatology Department, Centre Hospitalo-Universitaire d'Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Leftheriotis+G%22">Leftheriotis G</searchLink>; Université Côte d'Azur, CNRS, LP2M, Nice, France. leftheriotis.g@chu-nice.fr.; National Center for Rare Arterial Diseases, Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France. leftheriotis.g@chu-nice.fr.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE
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