Neuroactive steroid biosynthesis during pregnancy predicts future postpartum depression: a role for the 3α and/or 3β-HSD neurosteroidogenic enzymes?

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Title: Neuroactive steroid biosynthesis during pregnancy predicts future postpartum depression: a role for the 3α and/or 3β-HSD neurosteroidogenic enzymes?
Authors: Osborne LM; Department of Obstetrics & Gynecology, Weill Cornell Medical College, New York, NY, USA. lmo2003@med.cornell.edu.; Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA. lmo2003@med.cornell.edu., Etyemez S; Department of Obstetrics & Gynecology, Weill Cornell Medical College, New York, NY, USA.; Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA., Pinna G; Department of Psychiatry, The Psychiatric Institute, University of Illinois, Chicago, IL, USA., Alemani R; Department of Psychiatry, The Psychiatric Institute, University of Illinois, Chicago, IL, USA., Standeven LR; Department of Psychiatry, University of Colorado School of Medicine, Denver, CO, USA., Wang XQ; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Payne JL; Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA.
Source: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2025 May; Vol. 50 (6), pp. 904-912. Date of Electronic Publication: 2025 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1740-634X
DOI:10.1038/s41386-025-02052-z