Exploration of anti-inflammatory activity of pyrazolo[3,4-d]pyrimidine/1,2,4-oxadiazole hybrids as COX-2, 5-LOX and NO release inhibitors: Design, synthesis, in silico and in vivo studies.
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| Title: | Exploration of anti-inflammatory activity of pyrazolo[3,4-d]pyrimidine/1,2,4-oxadiazole hybrids as COX-2, 5-LOX and NO release inhibitors: Design, synthesis, in silico and in vivo studies. |
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| Authors: | Aziz MA; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519 Egypt., Salem IM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sphinx University, New Assiut City, Assiut 71515, Egypt., Al-Awadh MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Alharbi AS; Department of Chemistry, College of Science and Humanities-Dawadmi, Shaqra University, Saudi Arabia., Elsayed Abouzed DE; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt., Allam RM; Pharmacology Department, Medical Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt., Ahmed OAA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, 21589 Jeddah, Saudi Arabia; Mohamed Saeed Tamer Chair for Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Ibrahim TS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Abuo-Rahma GEA; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519 Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New Minia, Egypt. Electronic address: gamal.aborahma@mu.edu.eg., Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt. Electronic address: mamdouh.fawzi@pharm.sohag.edu.eg. |
| Source: | Bioorganic chemistry [Bioorg Chem] 2025 Mar; Vol. 156, pp. 108181. Date of Electronic Publication: 2025 Jan 22. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39889555 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Exploration of anti-inflammatory activity of pyrazolo[3,4-d]pyrimidine/1,2,4-oxadiazole hybrids as COX-2, 5-LOX and NO release inhibitors: Design, synthesis, in silico and in vivo studies. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Aziz+MA%22">Aziz MA</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519 Egypt.<br /><searchLink fieldCode="AU" term="%22Salem+IM%22">Salem IM</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sphinx University, New Assiut City, Assiut 71515, Egypt.<br /><searchLink fieldCode="AU" term="%22Al-Awadh+MA%22">Al-Awadh MA</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alharbi+AS%22">Alharbi AS</searchLink>; Department of Chemistry, College of Science and Humanities-Dawadmi, Shaqra University, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Elsayed+Abouzed+DE%22">Elsayed Abouzed DE</searchLink>; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt.<br /><searchLink fieldCode="AU" term="%22Allam+RM%22">Allam RM</searchLink>; Pharmacology Department, Medical Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt.<br /><searchLink fieldCode="AU" term="%22Ahmed+OAA%22">Ahmed OAA</searchLink>; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, 21589 Jeddah, Saudi Arabia; Mohamed Saeed Tamer Chair for Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ibrahim+TS%22">Ibrahim TS</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Abuo-Rahma+GEA%22">Abuo-Rahma GEA</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519 Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New Minia, Egypt. Electronic address: gamal.aborahma@mu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Mohamed+MFA%22">Mohamed MFA</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt. Electronic address: mamdouh.fawzi@pharm.sohag.edu.eg. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2025 Mar; Vol. 156, pp. 108181. <i>Date of Electronic Publication: </i>2025 Jan 22. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>1303703 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2120 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200452068%22">00452068 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39889555 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.bioorg.2025.108181 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 108181 Titles: – TitleFull: Exploration of anti-inflammatory activity of pyrazolo[3,4-d]pyrimidine/1,2,4-oxadiazole hybrids as COX-2, 5-LOX and NO release inhibitors: Design, synthesis, in silico and in vivo studies. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Aziz MA – PersonEntity: Name: NameFull: Salem IM – PersonEntity: Name: NameFull: Al-Awadh MA – PersonEntity: Name: NameFull: Alharbi AS – PersonEntity: Name: NameFull: Elsayed Abouzed DE – PersonEntity: Name: NameFull: Allam RM – PersonEntity: Name: NameFull: Ahmed OAA – PersonEntity: Name: NameFull: Ibrahim TS – PersonEntity: Name: NameFull: Abuo-Rahma GEA – PersonEntity: Name: NameFull: Mohamed MFA IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2025 Mar Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1090-2120 Numbering: – Type: volume Value: 156 Titles: – TitleFull: Bioorganic chemistry Type: main |
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