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A PARP2 active site helix melts to permit DNA damage-induced enzymatic activation.

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Title: A PARP2 active site helix melts to permit DNA damage-induced enzymatic activation.
Authors: Smith-Pillet ES; Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19140-6059, USA; Graduate Program in Biochemistry, Biophysics, Chemical Biology, University of Pennsylvania, Philadelphia, PA 19140-6059, USA., Billur R; Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19140-6059, USA., Langelier MF; Département de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, QC H3C 3J7, Canada., Talele TT; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA., Pascal JM; Département de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, QC H3C 3J7, Canada., Black BE; Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19140-6059, USA; Graduate Program in Biochemistry, Biophysics, Chemical Biology, University of Pennsylvania, Philadelphia, PA 19140-6059, USA. Electronic address: blackbe@pennmedicine.upenn.edu.
Source: Molecular cell [Mol Cell] 2025 Mar 06; Vol. 85 (5), pp. 865-876.e4. Date of Electronic Publication: 2025 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A PARP2 active site helix melts to permit DNA damage-induced enzymatic activation.
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  Data: <searchLink fieldCode="AU" term="%22Smith-Pillet+ES%22">Smith-Pillet ES</searchLink>; Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19140-6059, USA; Graduate Program in Biochemistry, Biophysics, Chemical Biology, University of Pennsylvania, Philadelphia, PA 19140-6059, USA.<br /><searchLink fieldCode="AU" term="%22Billur+R%22">Billur R</searchLink>; Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19140-6059, USA.<br /><searchLink fieldCode="AU" term="%22Langelier+MF%22">Langelier MF</searchLink>; Département de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Talele+TT%22">Talele TT</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.<br /><searchLink fieldCode="AU" term="%22Pascal+JM%22">Pascal JM</searchLink>; Département de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Black+BE%22">Black BE</searchLink>; Department of Biochemistry and Biophysics, Penn Center for Genome Integrity, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19140-6059, USA; Graduate Program in Biochemistry, Biophysics, Chemical Biology, University of Pennsylvania, Philadelphia, PA 19140-6059, USA. Electronic address: blackbe@pennmedicine.upenn.edu.
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  Data: <searchLink fieldCode="JN" term="%229802571%22">Molecular cell</searchLink> [Mol Cell] 2025 Mar 06; Vol. 85 (5), pp. 865-876.e4. <i>Date of Electronic Publication: </i>2025 Jan 30.
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