Protocol for functional screening of CFTR-targeted genetic therapies in patient-derived organoids using DETECTOR deep-learning-based analysis.

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Title: Protocol for functional screening of CFTR-targeted genetic therapies in patient-derived organoids using DETECTOR deep-learning-based analysis.
Authors: Bulcaen M; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium; Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium. Electronic address: bulcaen2@gmail.com., Liu RB; Department of Biosystems, KU Leuven, 3001 Leuven, Belgium; Institute for Imaging, Data and Communication, University of Edinburgh, Edinburgh EH93JL, UK. Electronic address: bingnan.liu@kuleuven.be., Gryspeert K; Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium. Electronic address: kasper.gryspeert@kuleuven.be., Thierie S; Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium., Ramalho AS; Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium., Vermeulen F; Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium; Department of Pediatrics, UZ Leuven, 3000 Leuven, Belgium., Casadevall I Solvas X; Department of Biosystems, KU Leuven, 3001 Leuven, Belgium., Carlon MS; Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium. Electronic address: marianne.carlon@kuleuven.be.
Source: STAR protocols [STAR Protoc] 2025 Mar 21; Vol. 6 (1), pp. 103593. Date of Electronic Publication: 2025 Jan 31.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-1667 (Electronic) Linking ISSN: 26661667 NLM ISO Abbreviation: STAR Protoc Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-1667
DOI:10.1016/j.xpro.2024.103593