Protocol for functional screening of CFTR-targeted genetic therapies in patient-derived organoids using DETECTOR deep-learning-based analysis.

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Title: Protocol for functional screening of CFTR-targeted genetic therapies in patient-derived organoids using DETECTOR deep-learning-based analysis.
Authors: Bulcaen M; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium; Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium. Electronic address: bulcaen2@gmail.com., Liu RB; Department of Biosystems, KU Leuven, 3001 Leuven, Belgium; Institute for Imaging, Data and Communication, University of Edinburgh, Edinburgh EH93JL, UK. Electronic address: bingnan.liu@kuleuven.be., Gryspeert K; Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium. Electronic address: kasper.gryspeert@kuleuven.be., Thierie S; Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium., Ramalho AS; Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium., Vermeulen F; Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium; Department of Pediatrics, UZ Leuven, 3000 Leuven, Belgium., Casadevall I Solvas X; Department of Biosystems, KU Leuven, 3001 Leuven, Belgium., Carlon MS; Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium. Electronic address: marianne.carlon@kuleuven.be.
Source: STAR protocols [STAR Protoc] 2025 Mar 21; Vol. 6 (1), pp. 103593. Date of Electronic Publication: 2025 Jan 31.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-1667 (Electronic) Linking ISSN: 26661667 NLM ISO Abbreviation: STAR Protoc Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Protocol for functional screening of CFTR-targeted genetic therapies in patient-derived organoids using DETECTOR deep-learning-based analysis.
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  Data: <searchLink fieldCode="AU" term="%22Bulcaen+M%22">Bulcaen M</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium; Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium. Electronic address: bulcaen2@gmail.com.<br /><searchLink fieldCode="AU" term="%22Liu+RB%22">Liu RB</searchLink>; Department of Biosystems, KU Leuven, 3001 Leuven, Belgium; Institute for Imaging, Data and Communication, University of Edinburgh, Edinburgh EH93JL, UK. Electronic address: bingnan.liu@kuleuven.be.<br /><searchLink fieldCode="AU" term="%22Gryspeert+K%22">Gryspeert K</searchLink>; Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium. Electronic address: kasper.gryspeert@kuleuven.be.<br /><searchLink fieldCode="AU" term="%22Thierie+S%22">Thierie S</searchLink>; Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Ramalho+AS%22">Ramalho AS</searchLink>; Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Vermeulen+F%22">Vermeulen F</searchLink>; Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium; Department of Pediatrics, UZ Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Casadevall+I+Solvas+X%22">Casadevall I Solvas X</searchLink>; Department of Biosystems, KU Leuven, 3001 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Carlon+MS%22">Carlon MS</searchLink>; Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium. Electronic address: marianne.carlon@kuleuven.be.
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  Data: <searchLink fieldCode="JN" term="%22101769501%22">STAR protocols</searchLink> [STAR Protoc] 2025 Mar 21; Vol. 6 (1), pp. 103593. <i>Date of Electronic Publication: </i>2025 Jan 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101769501 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2666-1667 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226661667%22">26661667 </searchLink><i>NLM ISO Abbreviation: </i>STAR Protoc <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.xpro.2024.103593
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              Text: 2025 Mar 21
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