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Characterization of Rationally Designed CRISPR/Cas9-Based DNA Methyltransferases with Distinct Methyltransferase and Gene Silencing Activities in Human Cell Lines and Primary Human T Cells.

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Bibliographic Details
Title: Characterization of Rationally Designed CRISPR/Cas9-Based DNA Methyltransferases with Distinct Methyltransferase and Gene Silencing Activities in Human Cell Lines and Primary Human T Cells.
Authors: Guerra-Resendez RS; Systems, Synthetic, and Physical Biology Program, Rice University, Houston, Texas 77005, United States., Lydon SL; Department of Bioengineering, Rice University, Houston, Texas 77005, United States., Ma AJ; Department of Bioengineering, Rice University, Houston, Texas 77005, United States., Bedford GC; Department of Bioengineering, Rice University, Houston, Texas 77005, United States., Reed DR; Department of Bioengineering, Rice University, Houston, Texas 77005, United States., Kim S; Department of Bioengineering, Rice University, Houston, Texas 77005, United States., Terán ER; Department of BioSciences, Rice University, Houston, Texas 77005, United States., Nishiguchi T; Global Tuberculosis Program, Texas Children's Hospital, Immigrant and Global Health, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, United States., Escobar M; Department of Bioengineering, Rice University, Houston, Texas 77005, United States., DiNardo AR; Global Tuberculosis Program, Texas Children's Hospital, Immigrant and Global Health, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, United States., Hilton IB; Systems, Synthetic, and Physical Biology Program, Rice University, Houston, Texas 77005, United States.; Department of Bioengineering, Rice University, Houston, Texas 77005, United States.; Department of BioSciences, Rice University, Houston, Texas 77005, United States.
Source: ACS synthetic biology [ACS Synth Biol] 2025 Feb 21; Vol. 14 (2), pp. 384-397. Date of Electronic Publication: 2025 Feb 03.
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101575075 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2161-5063 (Electronic) Linking ISSN: 21615063 NLM ISO Abbreviation: ACS Synth Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2161-5063
DOI:10.1021/acssynbio.4c00569