Biomolecular condensation of human IDRs initiates endogenous transcription via intrachromosomal looping or high-density promoter localization.

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Title: Biomolecular condensation of human IDRs initiates endogenous transcription via intrachromosomal looping or high-density promoter localization.
Authors: Li J; Department of Bioengineering, Rice University, Houston, TX, 77030, United States., Liu S; Department of BioSciences, Rice University, Houston, TX, 77030, United States., Kim S; Department of Bioengineering, Rice University, Houston, TX, 77030, United States., Goell J; Department of Bioengineering, Rice University, Houston, TX, 77030, United States., Drum ZA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, United States., Flores JP; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, United States., Ma AJ; Department of Bioengineering, Rice University, Houston, TX, 77030, United States., Mahata B; Department of Bioengineering, Rice University, Houston, TX, 77030, United States., Escobar M; Department of Bioengineering, Rice University, Houston, TX, 77030, United States., Raterink A; Systems, Synthetic, and Physical Biology Graduate Program, Rice University, Houston, TX, 77030, United States., Ahn JH; Lineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, United States., Terán ER; Department of BioSciences, Rice University, Houston, TX, 77030, United States., Guerra-Resendez RS; Systems, Synthetic, and Physical Biology Graduate Program, Rice University, Houston, TX, 77030, United States., Zhou Y; Department of Bioengineering, Rice University, Houston, TX, 77030, United States., Yu B; Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China., Diehl MR; Department of Bioengineering, Rice University, Houston, TX, 77030, United States.; Department of Chemistry, Rice University, Houston, TX, 77030, United States., Wang GG; Lineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, United States.; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC, 27710, United States., Gustavsson AK; Department of BioSciences, Rice University, Houston, TX, 77030, United States.; Systems, Synthetic, and Physical Biology Graduate Program, Rice University, Houston, TX, 77030, United States.; Department of Chemistry, Rice University, Houston, TX, 77030, United States., Phanstiel DH; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, United States., Hilton IB; Department of Bioengineering, Rice University, Houston, TX, 77030, United States.; Department of BioSciences, Rice University, Houston, TX, 77030, United States.; Systems, Synthetic, and Physical Biology Graduate Program, Rice University, Houston, TX, 77030, United States.
Source: Nucleic acids research [Nucleic Acids Res] 2025 Feb 08; Vol. 53 (4).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1362-4962
DOI:10.1093/nar/gkaf056