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High-throughput in vitro drug screening and in vivo studies identify fenretinide as a brain-penetrant DMG therapeutic.

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Title: High-throughput in vitro drug screening and in vivo studies identify fenretinide as a brain-penetrant DMG therapeutic.
Authors: Upton DH; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Liu J; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., George SM; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Valvi S; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Ung C; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Rayner BS; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Gopalakrishnan A; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Pandher R; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Khan A; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Venkat P; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Mayoh C; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Holliday H; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Yeung N; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Nguyen H; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Franshaw L; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Ehteda A; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Shen H; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Farruggia G; Alma Mater Studiorum University of Bologna, Department of Pharmacy and Biotechnology, Bologna, Italy., Orienti I; Alma Mater Studiorum University of Bologna, Department of Pharmacy and Biotechnology, Bologna, Italy., Reynolds CP; Cancer Center, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA., Tsoli M; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Ziegler DS; Kid's Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia.; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.
Source: Neuro-oncology [Neuro Oncol] 2025 Sep 08; Vol. 27 (7), pp. 1813-1828.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: High-throughput in vitro drug screening and in vivo studies identify fenretinide as a brain-penetrant DMG therapeutic.
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  Data: <searchLink fieldCode="AU" term="%22Upton+DH%22">Upton DH</searchLink>; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22George+SM%22">George SM</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Valvi+S%22">Valvi S</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ung+C%22">Ung C</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Rayner+BS%22">Rayner BS</searchLink>; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Gopalakrishnan+A%22">Gopalakrishnan A</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Pandher+R%22">Pandher R</searchLink>; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Khan+A%22">Khan A</searchLink>; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Venkat+P%22">Venkat P</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Mayoh+C%22">Mayoh C</searchLink>; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Holliday+H%22">Holliday H</searchLink>; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Yeung+N%22">Yeung N</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Nguyen+H%22">Nguyen H</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Franshaw+L%22">Franshaw L</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ehteda+A%22">Ehteda A</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Shen+H%22">Shen H</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Farruggia+G%22">Farruggia G</searchLink>; Alma Mater Studiorum University of Bologna, Department of Pharmacy and Biotechnology, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Orienti+I%22">Orienti I</searchLink>; Alma Mater Studiorum University of Bologna, Department of Pharmacy and Biotechnology, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Reynolds+CP%22">Reynolds CP</searchLink>; Cancer Center, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.<br /><searchLink fieldCode="AU" term="%22Tsoli+M%22">Tsoli M</searchLink>; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ziegler+DS%22">Ziegler DS</searchLink>; Kid's Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia.; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100887420 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1523-5866 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215228517%22">15228517 </searchLink><i>NLM ISO Abbreviation: </i>Neuro Oncol <i>Subsets: </i>MEDLINE
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