Lysosomal NKG7 restrains mTORC1 activity to promote CD8+ T cell durability and tumor control.
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| Title: | Lysosomal NKG7 restrains mTORC1 activity to promote CD8+ T cell durability and tumor control. |
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| Authors: | Ham H; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA. ham.hyoungjun@mayo.edu.; Department of Urology, Mayo Clinic, Rochester, MN, USA. ham.hyoungjun@mayo.edu., Hirdler JB; Department of Urology, Mayo Clinic, Rochester, MN, USA., Bihnam DT; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA., Mao Z; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Gicobi JK; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Macedo BG; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA., Rodriguez-Quevedo MF; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA., Schultz DF; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA., Correia C; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., Zhong J; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Martinez KE; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Banuelos A; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA., Ashton DS; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Lagnado AB; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Guo R; Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USA., Pessoa R; Department of Urology, Mayo Clinic, Rochester, MN, USA., Pandey A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Manipal Academy of Higher Education, Manipal, Karnataka, India., Li H; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., Lucien F; Department of Urology, Mayo Clinic, Rochester, MN, USA., Borges da Silva H; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA., Dong H; Department of Urology, Mayo Clinic, Rochester, MN, USA.; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Billadeau DD; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA. billadeau.daniel@mayo.edu.; Department of Immunology, Mayo Clinic, Rochester, MN, USA. billadeau.daniel@mayo.edu. |
| Source: | Nature communications [Nat Commun] 2025 Feb 14; Vol. 16 (1), pp. 1628. Date of Electronic Publication: 2025 Feb 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-56931-6 |
