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Lysosomal NKG7 restrains mTORC1 activity to promote CD8+ T cell durability and tumor control.

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Title: Lysosomal NKG7 restrains mTORC1 activity to promote CD8+ T cell durability and tumor control.
Authors: Ham H; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA. ham.hyoungjun@mayo.edu.; Department of Urology, Mayo Clinic, Rochester, MN, USA. ham.hyoungjun@mayo.edu., Hirdler JB; Department of Urology, Mayo Clinic, Rochester, MN, USA., Bihnam DT; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA., Mao Z; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Gicobi JK; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Macedo BG; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA., Rodriguez-Quevedo MF; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA., Schultz DF; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA., Correia C; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., Zhong J; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Martinez KE; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Banuelos A; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA., Ashton DS; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Lagnado AB; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Guo R; Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USA., Pessoa R; Department of Urology, Mayo Clinic, Rochester, MN, USA., Pandey A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Manipal Academy of Higher Education, Manipal, Karnataka, India., Li H; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., Lucien F; Department of Urology, Mayo Clinic, Rochester, MN, USA., Borges da Silva H; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA., Dong H; Department of Urology, Mayo Clinic, Rochester, MN, USA.; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Billadeau DD; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA. billadeau.daniel@mayo.edu.; Department of Immunology, Mayo Clinic, Rochester, MN, USA. billadeau.daniel@mayo.edu.
Source: Nature communications [Nat Commun] 2025 Feb 14; Vol. 16 (1), pp. 1628. Date of Electronic Publication: 2025 Feb 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lysosomal NKG7 restrains mTORC1 activity to promote CD8<superscript>+</superscript> T cell durability and tumor control.
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  Data: <searchLink fieldCode="AU" term="%22Ham+H%22">Ham H</searchLink>; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA. ham.hyoungjun@mayo.edu.; Department of Urology, Mayo Clinic, Rochester, MN, USA. ham.hyoungjun@mayo.edu.<br /><searchLink fieldCode="AU" term="%22Hirdler+JB%22">Hirdler JB</searchLink>; Department of Urology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Bihnam+DT%22">Bihnam DT</searchLink>; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Mao+Z%22">Mao Z</searchLink>; Department of Immunology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Gicobi+JK%22">Gicobi JK</searchLink>; Department of Immunology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Macedo+BG%22">Macedo BG</searchLink>; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Quevedo+MF%22">Rodriguez-Quevedo MF</searchLink>; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Schultz+DF%22">Schultz DF</searchLink>; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Correia+C%22">Correia C</searchLink>; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Zhong+J%22">Zhong J</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+KE%22">Martinez KE</searchLink>; Department of Immunology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Banuelos+A%22">Banuelos A</searchLink>; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Ashton+DS%22">Ashton DS</searchLink>; Department of Immunology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Lagnado+AB%22">Lagnado AB</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Guo+R%22">Guo R</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Pessoa+R%22">Pessoa R</searchLink>; Department of Urology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pandey+A%22">Pandey A</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Manipal Academy of Higher Education, Manipal, Karnataka, India.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Lucien+F%22">Lucien F</searchLink>; Department of Urology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Borges+da+Silva+H%22">Borges da Silva H</searchLink>; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Dong+H%22">Dong H</searchLink>; Department of Urology, Mayo Clinic, Rochester, MN, USA.; Department of Immunology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Billadeau+DD%22">Billadeau DD</searchLink>; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA. billadeau.daniel@mayo.edu.; Department of Immunology, Mayo Clinic, Rochester, MN, USA. billadeau.daniel@mayo.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Feb 14; Vol. 16 (1), pp. 1628. <i>Date of Electronic Publication: </i>2025 Feb 14.
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